Analytical Data
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基因名
SEC61A2
- Application
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别名
SEC61A2; Protein transport protein Sec61 subunit alpha isoform 2; Sec61 alpha-2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H9S3
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表达区间
1-476 aa
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氨基酸序列
MGIKFLEVIKPFCAVLPEIQKPERKIQFREKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMIITIGQAIVYVMTGMYGDPAEMGAGICLLIIIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTINTGRGTEFEGAVIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATVFVFAVVIYFQGFRVDLPIKSARYRGQYSSYPIKLFYTSNIPIILQSALVSNLYVISQMLSVRFSGNFLVNLLGQWADVSGGGPARSYPVGGLCYYLSPPESMGAIFEDPVHVVVYIIFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRDTSMVHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQAEVGGMGALFF
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分子量
78.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SEC61A2 is a key component of the Sec61 translocon complex, which plays a crucial role in the translocation of proteins across the endoplasmic reticulum (ER) membrane. This protein facilitates the proper folding and maturation of nascent polypeptides as they enter the ER, influencing a wide array of cellular processes, including secretion and membrane biogenesis. Recent studies have highlighted the significance of SEC61A2 in various physiological and pathological contexts, including its involvement in the immune response and potential links to diseases such as cancer and neurodegenerative disorders. Recombinant SEC61A2 proteins are of great interest for biochemical and structural studies, enabling researchers to dissect the molecular mechanisms governing protein translocation and membrane interactions. Furthermore, understanding the functional dynamics of SEC61A2 can provide insights into the therapeutic targeting of the translocon complex in diseases characterized by dysregulated protein synthesis or misfolding. The continuous exploration of SEC61A2's role in cellular physiology and its potential as a drug target underscores the importance of this protein in both basic research and clinical applications, making it a focal point of current biochemistry and molecular biology investigations.
