Analytical Data
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基因名
ARHGAP19
- Application
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别名
ARHGAP19；Rho GTPase-activating Protein 19
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q14CB8
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表达区间
1-494aa
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氨基酸序列
MMMMALSKTFGQKPVKFQLEDDGEFYMIGSEVGNYLRMFRGSLYKRYPSLWRRLATVEERKKIVASSHGKKTKPNTKDHGYTTLATSVTLLKASEVEEILDGNDEKYKAVSISTEPPTYLREQKAKRNSQWVPTLPNSSHHLDAVPCSTTINRNRMGRDKKRTFPLCFDDHDPAVIHENASQPEVLVPIRLDMEIDGQKLRDAFTWNMNEKLMTPEMFSEILCDDLDLNPLTFVPAIASAIRQQIESYPTDSILEDQSDQRVIIKLNIHVGNISLVDQFEWDMSEKENSPEKFALKLCSELGLGGEFVTTIAYSIRGQLSWHQKTYAFSENPLPTVEIAIRNTGDADQWCPLLETLTDAEMEKKIRDQDRNTRRMRRLANTAPAW
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分子量
60.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ARHGAP19 (Rho GTPase-activating protein 19) is a member of the Rho GTPase-activating protein family, which plays a crucial role in regulating cellular functions such as cytoskeletal organization, cell migration, and signal transduction. The study of ARHGAP19 has gained attention due to its potential involvement in various physiological and pathological processes, including neuronal development and cognitive functions. Recent research has indicated that ARHGAP19 may be implicated in neurodevelopmental disorders such as autism spectrum disorder and schizophrenia, as mutations or dysregulation of this gene can disrupt neuronal signaling pathways. Furthermore, the protein's role in modulating the Rho family of GTPases, particularly RhoA, has been linked to the regulation of actin dynamics and cell adhesion, highlighting its importance in maintaining cellular architecture and function. As a result, the characterization of ARHGAP19, including its recombinant protein studies, becomes a pivotal aspect of understanding its biological significance and therapeutic potential. Investigating the biochemical properties, interactions, and pathways associated with ARHGAP19 can contribute to the development of targeted interventions for diseases related to its dysregulation. Overall, the exploration of ARHGAP19 and its recombinant protein presents a promising avenue for advancing our knowledge of cellular mechanisms and identifying novel strategies for therapeutic applications.
