Analytical Data
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基因名
SEC31B
- Application
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别名
SEC31L2; Gm341; Protein transport protein Sec31B; SC31B_HUMAN; SEC31 B; SEC31 homolog B (S. cerevisiae); SEC31 homolog B; SEC31 like 2; SEC31 related protein B; SEC31-like protein 2; SEC31-related protein B; SEC31B 1; SEC31B; SEC31B-1; Secretory pathway component Sec31B 1; secretory pathway component Sec31B1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NQW1
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表达区间
1-348 aa
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氨基酸序列
MKLKELERPAVQAWSPASQYPLYLATGTSAQQLDSSFSTNGTLEIFEVDFRDPSLDLKHRGVLSALSRFHKLVWGSFGSGLLESSGVIAGGGDNGMLILYNVTHILSSGKEPVIAQKQKHTGAVRALDFNPFQGNLLASGASDSEIFIWDLNNLNVPMTLGSKSQPPEDIKALSWNRQAQHILSSAHPSGKAVVWDLRKNEPIIKVSDHSNRMHCSGLAWHPDIATQLVLCSEDDRLPVIQLWDLRFASSPLKVLESHSRGILSVSWSQADAELLLTSAKDSQILCRNLGSSEVVYKLPTQSSWCFDVQWCPRDPSVFSAASFNGWISLYAVMGRSWEVQHMRQADKV
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分子量
64.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SEC31B, a member of the SEC31 protein family, plays a crucial role in the secretory pathway of eukaryotic cells, particularly in the formation of the coatomer complex during vesicle budding from the endoplasmic reticulum. This protein is essential for the transport of proteins and lipids from the endoplasmic reticulum to the Golgi apparatus, thereby facilitating cellular communication, secretion processes, and overall membrane dynamics. Research into SEC31B has garnered attention due to its potential links to various diseases, including certain neurodegenerative disorders and metabolic syndromes, where dysfunctional protein transport may contribute to cellular stress and pathology. Furthermore, SEC31B's involvement in the regulation of cellular homeostasis and its interaction with other proteins in the secretory pathway highlights its significance in maintaining proper cellular function. Investigating SEC31B at the molecular level could yield insights into its mechanisms and regulatory roles, ultimately leading to the development of therapeutic interventions aimed at rectifying transport-related disorders. Given its pivotal role, the recombinant expression of SEC31B protein has become an important avenue for research, enabling scientists to explore its structure-function relationship, interaction dynamics with other proteins, and implications in health and disease, thereby contributing to the broader understanding of cellular transport mechanisms.
