Analytical Data
-
Gene name
GM2A
- Application
-
Alternative Names
GM2A；Ganglioside GM2 activator
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P17900
-
Expression Region
26-193aa
-
AA Sequence
KKPSQLSSFS WDNCDEGKDP AVIRSLTLEP DPIIVPGNVT LSVMGSTSVP LSSPLKVDLV LEKEVAGLWI KIPCTDYIGS CTFEHFCDVL DMLIPTGEPC PEPLRTYGLP CHCPFKEGTY SLPKSEFVVP DLELPSWLTT GNYRIESVLS SSGKRLGCIK IAASLKGI
-
Molecular Weight
19 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GM2A (GM2 ganglioside activator protein) is a vital protein involved in the metabolism of gangliosides, complex glycosphingolipids that play essential roles in cell signaling and neuronal function. Mutations in the GM2A gene lead to GM2 gangliosidosis, a group of lysosomal storage disorders, including the Tay-Sachs and Sandhoff diseases. These conditions result in the accumulation of GM2 gangliosides, causing severe neurological deficits and ultimately leading to premature death. The study of GM2A recombinant proteins has gained significant attention in the fields of molecular biology and medicine, as it offers insights into the biochemical pathways associated with ganglioside metabolism. Research on GM2A involves delineating its structure, function, and interactions with other proteins and lipids, which could pave the way for developing therapeutic strategies aimed at mitigating the effects of GM2 gangliosidosis. Additionally, the recombinant production of GM2A enables the exploration of its functional properties in vitro and the potential for enzyme replacement therapies. Understanding the mechanisms behind GM2A's activity and the pathological consequences of its deficiency can provide crucial information for developing targeted interventions for those affected by related disorders. Consequently, GM2A research represents a promising avenue for advancing our knowledge of neurodegenerative diseases and exploring potential treatment modalities.
