Analytical Data
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基因名
NR1I3
- Application
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别名
NR1I3；CAR；Nuclear receptor subfamily 1 group I member 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q14994
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表达区间
2-351aa
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氨基酸序列
ASREDELRNCVVCGDQATGYHFNALTCEGCKGFFRRTVSKSIGPTCPFAGSCEVSKTQRRHCPACRLQKCLDAGMRKDMILSAEALALRRAKQAQRRAQQTPVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLFIHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLPVFRSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPLRYTIEDGARVSPTVGFQVEFLELLFHFHGTLRKLQLQEPEYVLLAAMALFSPDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRRPRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPLLQEIC
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分子量
40 KDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NR1I3, also known as the pregnane X receptor (PXR), is a member of the nuclear receptor superfamily that plays a critical role in drug metabolism and detoxification processes. It is primarily involved in the regulation of genes responsible for the metabolism of xenobiotics and endogenous compounds. The interest in NR1I3 has surged due to its implications in pharmacogenomics, toxicology, and drug-drug interactions, which are essential for personalized medicine. Research into NR1I3 has revealed its ability to sense and respond to a diverse range of ligands, including prescription medications, dietary supplements, and environmental pollutants. These findings suggest that NR1I3 is not only pivotal in the liver's metabolic response but also crucial in various therapeutic areas, including cancer and metabolic diseases. The study of NR1I3's recombinant protein is significant for understanding its structure-function relationships, ligand-binding characteristics, and regulatory mechanisms. Furthermore, NR1I3 serves as a potential target for drug design aimed at modulating its activity for therapeutic advantages. This growing body of research highlights the importance of NR1I3 in advancing our understanding of human health and disease, illustrating its potential role in improving drug efficacy and safety profiles.
