Analytical Data
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基因名
CKMT1B
- Application
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别名
CKMT; CKMT1; CKMT1B; Creatine kinase mitochondrial 1 (ubiquitous); Creatine kinase mitochondrial 1B; Creatine kinase U type mitochondrial
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P12532
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表达区间
40-417aa
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氨基酸序列
ASERRRLYPPSAEYPDLRKHNNCMASHLTPAVYARLCDKTTPTGWTLDQCIQTGVDNPGHPFIKTVGMVAGDEETYEVFADLFDPVIQERHNGYDPRTMKHTTDLDASKIRSGYFDERYVLSSRVRTGRSIRGLSLPPACTRAERREVERVVVDALSGLKGDLAGRYYRLSEMTEAEQQQLIDDHFLFDKPVSPLLTAAGMARDWPDARGIWHNNEKSFLIWVNEEDHTRVISMEKGGNMKRVFERFCRGLKEVERLIQERGWEFMWNERLGYILTCPSNLGTGLRAGVHIKLPLLSKDSRFPKILENLRLQKRGTGGVDTAATGGVFDISNLDRLGKSEVELVQLVIDGVNYLIDCERRLERGQDIRIPTPVIHTKH
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分子量
47.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CKMT1B, or creatine kinase mitochondrial 1B, is a critical enzyme involved in cellular energy metabolism, particularly within the mitochondria, where it plays a crucial role in maintaining ATP levels and facilitating the transport of creatine and phosphocreatine. Research on CKMT1B has garnered significant interest due to its implications in muscle function, neuroprotection, and various pathological conditions, including mitochondrial diseases and neurodegenerative disorders like Parkinson's and Alzheimer's. The expression and activity of CKMT1B can be influenced by factors such as oxidative stress and metabolic dysregulation, making it a potential biomarker and therapeutic target. Recombinant CKMT1B protein studies enable detailed investigations into its structural and functional properties, elucidating mechanisms of action and interactions within the mitochondrial environment. Additionally, the ability to produce recombinant CKMT1B protein facilitates high-throughput screening of potential drug candidates that could modulate its activity, offering promising avenues for developing treatments for related disorders. Overall, the research surrounding CKMT1B not only enhances our understanding of mitochondrial biology but also opens up new possibilities for therapeutic interventions in energy metabolism-related diseases.
