Analytical Data
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基因名
CMPK
- Application
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别名
CMK; CMPK 1; CMPK; cmpk1; Cytidine monophosphate (UMP CMP) kinase 1 cytosolic; Cytidine monophosphate kinase; Cytidine monophosphate UMP CMP kinase 1 cytosolic; Cytidylate kinase; dCMP kinase; Deoxycytidylate kinase; EC 2.7.4.14; KCY; KCY_HUMAN; Monophosphatase kinase; OTTHUMP00000009565; RP11 511I2.1; UCK
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P30085
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表达区间
1-196aa
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氨基酸序列
MKPLVVFVLG GPGAGKGTQC ARIVEKYGYT HLSAGELLRD ERKNPDSQYG ELIEKYIKEG KIVPVEITIS LLKREMDQTM AANAQKNKFL IDGFPRNQDN LQGWNKTMDG KADVSFVLFF DCNNEICIER CLERGKSSGR SDDNRESLEK RIQTYLQSTK PIIDLYEEMG KVKKIDASKS VDEVFDEVVQ IFDKEG
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分子量
22.2 KDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CMPK (cytidine monophosphate kinase) is an essential enzyme involved in nucleotide metabolism, playing a critical role in the phosphorylation of cytidine monophosphate (CMP) to cytidine diphosphate (CDP). This process is vital for RNA synthesis and cellular energy regulation. Research into CMPK has gained momentum due to its potential implications in various biological processes, including DNA repair, cell proliferation, and metabolic disorders. The importance of CMPK in maintaining nucleotide pools has made it a target for therapeutic interventions in diseases where nucleotide metabolism is disrupted, such as cancer and neurodegenerative disorders. Additionally, the study of CMPK's structure and function through recombinant protein techniques provides insight into its enzymatic mechanisms, substrate specificity, and potential regulatory pathways. By producing and characterizing recombinant CMPK, researchers aim to elucidate its role in cellular metabolism and explore its application in drug development. This research not only enhances our understanding of nucleotide biosynthesis but also paves the way for novel therapeutic strategies in treating diseases linked to metabolic dysregulation. The growing interest in CMPK reflects its significance in biochemistry and molecular biology, fostering advancements in both fundamental research and clinical applications.
