Analytical Data
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基因名
SIAH3
- Application
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别名
FLJ39203; Gm912; RP11-480G1.1; Seven in absentia homolog 3; Siah-3; SIAH3; SIAH3_HUMAN
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8IW03
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表达区间
1-269 aa
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氨基酸序列
MLFFTQCFGA VLDLIHLRFQ HYKAKRVFSA AGQLVCVVNP THNLKYVSSR RAVTQSAPEQ GSFHPHHLSH HHCHHRHHHH LRHHAHPHHL HHQEAGLHAN PVTPCLCMCP LFSCQWEGRL EVVVPHLRQI HRVDILQGAE IVFLATDMHL PAPADWIIMH SCLGHHFLLV LRKQERHEGH PQFFATMMLI GTPTQADCFT YRLELNRNHR RLKWEATPRS VLECVDSVIT DGDCLVLNTS LAQLFSDNGS LAIGIAITAT EVLPSEAEM
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分子量
30.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SIAH3, a member of the Siah (seven in absentia homologue) family of E3 ubiquitin ligases, has garnered significant attention in molecular biology and cancer research due to its crucial role in regulating protein stability and cellular responses to stress. Initially identified for its function in mediating the ubiquitination and subsequent degradation of various substrates, SIAH3 has been implicated in several key biological processes, including apoptosis, cell cycle regulation, and hypoxic responses. In the context of tumor biology, aberrant expression of SIAH3 is associated with the progression of various cancers, making it a potential biomarker and therapeutic target. Recent studies have revealed its involvement in the modulation of oncogenic signaling pathways, thus highlighting its significance in maintaining cellular homeostasis under pathological conditions. Moreover, the exploration of SIAH3's molecular functions and interactions has led to a deeper understanding of its role in the development and progression of malignancies, as well as its potential as a prognostic indicator. These findings underscore the need for further investigation into SIAH3's mechanisms of action, offering promising avenues for developing targeted therapeutics aimed at manipulating its activity in cancer treatment and improving patient outcomes.
