Analytical Data
-
基因名
RPS6KA6
- Application
-
别名
RPS6KA6；RSK4；Ribosomal Protein S6 kinase alpha-6
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q9UK32
-
表达区间
1-745aa
-
氨基酸序列
MLPFAPQDEP WDREMEVFSG GGASSGEVNG LKMVDEPMEE GEADSCHDEG VVKEIPITHH VKEGYEKADP AQFELLKVLG QGSFGKVFLV RKKTGPDAGQ LYAMKVLKKA SLKVRDRVRT KMERDILVEV NHPFIVKLHY AFQTEGKLYL ILDFLRGGDV FTRLSKEVLF TEEDVKFYLA ELALALDHLH QLGIVYRDLK PENILLDEIG HIKLTDFGLS KESVDQEKKA YSFCGTVEYM APEVVNRRGH SQSADWWSYG VLMFEMLTGT LPFQGKDRNE TMNMILKAKL GMPQFLSAEA QSLLRMLFKR NPANRLGSEG VEEIKRHLFF ANIDWDKLYK REVQPPFKPA SGKPDDTFCF DPEFTAKTPK DSPGLPASAN AHQLFKGFSF VATSIAEEYK ITPITSANVL PIVQINGNAA QFGEVYELKE DIGVGSYSVC KRCIHATTNM EFAVKIIDKS KRDPSEEIEI LMRYGQHPNI ITLKDVFDDG RYVYLVTDLM KGGELLDRIL KQKCFSEREA SDILYVISKT VDYLHCQGVV HRDLKPSNIL YMDESASADS IRICDFGFAK QLRGENGLLL TPCYTANFVA PEVLMQQGYD AACDIWSLGV LFYTMLAGYT PFANGPNDTP EEILLRIGNG KFSLSGGNWD NISDGAKDLL SHMLHMDPHQ RYTAEQILKH SWITHRDQLP NDQPKRNDVS HVVKGAMVAT YSALTHKTFQ PVLEPVAASS LAQRRSMKKR TSTGL
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Recombinant Human SHQ1 Protein，His
Cat：PAX2000-11302
Recombinant Human MAP2K6 Protein，His
Cat：PA1000-7421
Protein Description
RPS6KA6, also known as RSK4 (ribosomal S6 kinase 4), is a serine/threonine kinase that plays a crucial role in various cellular processes, including cell growth, proliferation, and survival. It is part of the RSK family of kinases, which are activated by mitogen-activated protein (MAP) kinase signaling pathways, primarily in response to extracellular stimuli. Research on RPS6KA6 is of particular interest due to its involvement in cancer biology, where dysregulation of signaling pathways often contributes to tumorigenesis. Studies have shown that RPS6KA6 can modulate multiple downstream target proteins, influencing essential processes such as protein synthesis and gene expression. Additionally, it has been suggested that RPS6KA6 may participate in the development of resistance to certain therapies, making it a potential target for therapeutic intervention. Given its diverse functions and implications in disease, including various cancers and neurological disorders, understanding the structure and function of RPS6KA6 through recombinant protein studies can provide critical insights into its biological roles and pave the way for potential clinical applications. Recombinant RPS6KA6 protein can be utilized to analyze its enzymatic activity, interaction with substrate proteins, and impact on signaling pathways, contributing to a deeper understanding of its function in health and disease.
