Analytical Data
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基因名
STK10
- Application
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别名
STK10；LOK；Serine/threonine-Protein kinase 10
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O94804
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表达区间
1-968aa
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氨基酸序列
MAFANFRRILRLSTFEKRKSREYEHVRRDLDPNEVWEIVGELGDGAFGKV YKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAY YHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHS KRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMA PEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIA KSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSN KALRELVAEAKAEVMEEIEDGRDEGEEEDAVDAASTLENHTQNSSEVSPP SLNADKPLEESPSTPLAPSQSQDSVNEPCSQPSGDRSLQTTSPPVVAPGN ENGLAVPVPLRKSRPVSMDARIQVAQEKQVAEQGGDLSPAANRSQKASQS RPNSSALETLGGEKLANGSLEPPAQAAPGPSKRDSDCSSLCTSESMDYGT NLSTDLSLNKEMGSLSIKDPKLYKKTLKRTRKFVVDGVEVSITTSKIISE DEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQ EINAKKKFFDTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDY TRFQEQLKLMKKEVKNEVEKLPRQQRKESMKQKMEEHTQKKQLLDRDFVA KQKEDLELAMKRLTTDNRREICDKERECLMKKQELLRDREAALWEMEEHQ LQERHQLVKQQLKDQYFLQRHELLRKHEKEREQMQRYNQRMIEQLKVRQQ QEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQREKIKQFSQQEEKR QKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCHLLVEHETQKLK ALDESHNQNLKEWRDKLRPRKKAL
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分子量
138 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
STK10, also known as serine/threonine kinase 10, is a member of the STE20-like kinase family, which plays a crucial role in various cellular processes, including cell cycle regulation, apoptosis, and immune response. Research has shown that STK10 is involved in the modulation of the actin cytoskeleton and has a significant role in hematopoiesis and lymphocyte development. Its dysregulation has been implicated in several diseases, including cancer and immune disorders, making it a potential target for therapeutic intervention. The study of STK10 recombinant proteins is critical for understanding its biochemical properties, signaling pathways, and role in cellular processes. By expressing STK10 as a recombinant protein, researchers can investigate its enzymatic functions, interaction with substrates, and involvement in cellular signaling networks. This research can also facilitate the development of STK10 inhibitors or activators that could be used in experimental or clinical settings to modulate its activity in disease models. Additionally, understanding the structure-function relationship of STK10 through recombinant protein studies can provide insights into its unique regulatory mechanisms and potential as a biomarker for various pathologies. Overall, the investigation of STK10 recombinant proteins represents a valuable avenue for advancing our knowledge of this kinase's role in health and disease.
