Analytical Data
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基因名
SLC12A6
- Application
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别名
ACCPN; Electroneutral potassium-chloride cotransporter 3; Furosemide sensitive KCl cotransporter 3; Gaxp; K-Cl cotransporter 3; KCC 3; KCC 3A; KCC 3B; KCC3 A; KCC3; KCC3 B; KCC3A; KCC3B; Potassium chloride cotransporter 3; Potassium chloride cotransporter KCC3a S3; S12A6_HUMAN; SLC12 A6; SLC12A 6; SLC12A6; Solute carrier family 12 (potassium/chloride transporters); member 6; Solute carrier family 12 member 6; Solute carrier family 12; member 6
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UHW9
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表达区间
1-90 aa
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氨基酸序列
MPHFTVTKVEDPEEGAAASISQEPSLADIKARIQDSDEPDLSQNSITGEHSQLLDDGHKKARNAYLNNSNYEEGDEYFDKNLALFEEEMD
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分子量
35.64 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC12A6 is a member of the solute carrier family and encodes a sodium-potassium-chloride co-transporter that plays a crucial role in ion homeostasis and cellular volume regulation. Recent studies have highlighted its significance in various physiological processes, including neuronal function and fluid balance. Mutations in SLC12A6 are associated with several neurological disorders, such as the early infantile epileptic encephalopathy (EIEE) characterized by seizures and cognitive impairment. Understanding the functional dynamics of SLC12A6 is critical, as it may provide insights into the underlying mechanisms of these diseases and identify potential therapeutic targets. Recombinant SLC12A6 protein is essential for studying the protein's structure, function, and interactions, allowing for the characterization of its transport activity and regulatory mechanisms in cellular models. This research facilitates the understanding of how SLC12A6 contributes to neuronal excitability and overall brain health, thereby advancing knowledge in both basic neuroscience and clinical applications. As a result, the production and study of recombinant SLC12A6 protein hold significant promise for unraveling the complexities of ion transport mechanisms and their implications in health and disease.
