Analytical Data
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基因名
CPNE2
- Application
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别名
CPNE2Copine-2; Copine II
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96FN4
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表达区间
1-548aa
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氨基酸序列
MAHIPSGGAPAAGAAPMGPQYCVCKVELSVSGQNLLDRDVTSKSDPFCVLFTENNGRWIEYDRTETAINNLNPAFSKKFVLDYHFEEVQKLKFALFDQDKSSMRLDEHDFLGQFSCSLGTIVSSKKITRPLLLLNDKPAGKGLITIAAQELSDNRVITLSLAGRRLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVIKYTLDPVWKPFTVPLVSLCDGDMEKPIQVMCYDYDNDGGHDFIGEFQTSVSQMCEARDSVPLEFECINPKKQRKKKNYKNSGIIILRSCKINRDYSFLDYILGGCQLMFTVGIDFTASNGNPLDPSSLHYINPMGTNEYLSAIWAVGQIIQDYDSDKMFPALGFGAQLPPDWKVSHEFAINFNPTNPFCSGVDGIAQAYSACLPHIRFYGPTNFSPIVNHVARFAAQATQQRTATQYFILLIITDGVISDMEETRHAVVQASKLPMSIIIVGVGNADFAAMEFLDGDSRMLRSHTGEEAARDIVQFVPFREFRNAAKETLAKAVLAELPQQVVQYFKHKNLPPTNSEPA
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分子量
87.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CPNE2 (Copine 2) is a member of the copine family, characterized by its unique structure that includes two homologous C2 domains and a young domain, which are thought to be involved in calcium-dependent membrane interactions. Research on CPNE2 has garnered attention due to its emerging role in various physiological processes, including neuronal signaling, cell migration, and apoptosis. Its expression is primarily observed in the brain, indicating potential implications in neurodevelopmental and neurodegenerative disorders. Studies have suggested that CPNE2 may act as a regulatory protein at synapses, influencing neurotransmitter release and synaptic plasticity, which are critical for learning and memory. Moreover, dysregulation of CPNE2 has been associated with several diseases, highlighting its importance as a potential biomarker or therapeutic target. The recombinant production of CPNE2 is pivotal for elucidating its structural and functional properties, allowing researchers to investigate its interaction with membranes and other cellular components. By generating CPNE2 in a recombinant system, researchers can explore its biochemical characteristics, assess its role in cell signaling pathways, and evaluate its potential applications in drug development and regenerative medicine. Overall, the study of CPNE2 is crucial for advancing our understanding of cellular processes in health and disease, making it a significant focus of ongoing research in molecular and cellular biology.
