Analytical Data
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基因名
CRK7
- Application
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别名
arginine/serine-rich; Cdc2 related kinase arginine/serine rich; CDC2 related protein kinase 7; Cdc2-related kinase; CDC2-related protein kinase 7; Cdk12; CDK12_HUMAN; Cell division cycle 2 related protein kinase 7; Cell division cycle 2-related protein kinase 7; Cell division protein kinase 12; CRK7
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NYV4
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表达区间
1281-1380aa
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氨基酸序列
LVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRPRPNRTYGNTDGPETGFSAIDTDERNSGPALTESLVQTLVKNRTFSGSL
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分子量
36.63 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CRK7, or cyclin-dependent kinase 7, is a crucial regulator in the cell cycle and transcriptional regulation, functioning as a component of the CDK-activating kinase (CAK) complex that phosphorylates and activates other cyclin-dependent kinases. Recent studies have highlighted its role beyond cell cycle regulation, including its involvement in transcriptional control of various genes, thereby influencing cellular response to stress and developmental processes. The interest in CRK7 has surged due to its connections to several diseases, including cancer, where dysregulation may lead to uncontrolled cell proliferation. Understanding CRK7's structure and function at the molecular level is essential for elucidating its precise role in these biological processes. Research on recombinant CRK7 proteins allows scientists to dissect its interactions with other cellular proteins and investigate potential inhibitory compounds that could serve as therapeutic agents. Moreover, studying CRK7 has implications for developing targeted therapies, especially in cancers that exhibit aberrant regulation of the cell cycle. Overall, the reconstituted CRK7 protein provides valuable insights into its mechanism of action and paves the way for future innovations in the treatment of related diseases.
