Analytical Data
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Gene name
CROCCL2
- Application
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Alternative Names
CROCCP3; CROCCL2; KIAA1922; Putative ciliary rootlet coiled-coil protein-like 2 protein; Ciliary rootlet coiled-coil protein pseudogene 3
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8IVE0
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Expression Region
1-287aa
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AA Sequence
MRGRYEASQD LLGTLRKQLS DSESERRALE EQLQRLRDKT DSTMQAHEDA QREVQRLRSA KELLRREKSN LAHSLQVAQQ QAKELRQERK KLQAAQEELR RQRYWLGEEQ EDAVQDGVRV RRELERSHRQ LEQLEGKRSV LAKELVEVRE ALSRATLQRD MLQAEKAEVA EALTKAEGRG GLPAGLPVQA ERPQREPCSG QVGSEPPCHP GHSWRKKSAP CRAGSGRRSR RPQWHGKSRS GWRRCGWNRR WRGRAWRAPY ERRSRPRRQW SSSSPRCIMS AAGCRSS
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Molecular Weight
59.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CROCCL2, also known as Chemokine (C-C motif) ligand 2, is a critical protein that plays a significant role in immune response and inflammation. It is primarily involved in the recruitment of monocytes, memory T cells, and dendritic cells to sites of inflammation, making it an important factor in various pathological conditions, including autoimmune diseases, chronic inflammatory disorders, and cancer. The increasing prevalence of these diseases highlights the need for a deeper understanding of CROCCL2's structure and function. Researchers have focused on the recombinant expression of CROCCL2 to facilitate the study of its biological properties and therapeutic potential. By producing CROCCL2 as a recombinant protein, scientists can investigate its interactions with specific receptors, elucidate its signaling pathways, and explore its role in disease progression. Moreover, recombinant CROCCL2 can be used in drug discovery and development, as it may serve as a target for novel anti-inflammatory therapies. The generation of CROCCL2 recombinant protein not only enhances our understanding of its biological significance but also opens new avenues for clinical applications aimed at modulating immune responses and improving patient outcomes in diseases characterized by dysregulated inflammation.
