Analytical Data
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Gene name
SMCHD1
- Application
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Alternative Names
BAMS; FSHD2; KIAA0650; SMC hinge domain containing 1; SMC hinge domain containing protein 1; Smchd1; SMHD1_HUMAN; Structural maintenance of chromosomes flexible hinge domain containing 1; Structural maintenance of chromosomes flexible hinge domain-containing protein 1
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
A6NHR9
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Expression Region
1-267 aa
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AA Sequence
MVISWHLASDMDCVVTLTTDAARRIYDETQGRQQVLPLDSIYKKTLPDWKRSLPHFRNGKLYFKPIGDPVFARDLLTFPDNVEHCETVFGMLLGDTIILDNLDAANHYRKEVVKITHCPTLLTRDGDRIRSNGKFGGLQNKAPPMDKLRGMVFGAPVPKQCLILGEQIDLLQQYRSAVCKLDSVNKDLNSQLEYLRTPDMRKKKQELDEHEKNLKLIEEKLGMTPIRKCNDSLRHSPKVETTDCPVPPKRMRREATRQNRIITKTDV
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Molecular Weight
57.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SMCHD1 (Structural Maintenance of Chromosomes Flexible Hinge Domain Containing 1) is a crucial protein that plays a significant role in chromosome architecture and gene regulation. Research on SMCHD1 has gained momentum due to its association with various genetic disorders, including facioscapulohumeral muscular dystrophy (FSHD), a hereditary condition characterized by muscle weakness and wasting. This protein functions as a chromatin remodeler and is implicated in the maintenance of genomic stability, influencing the silencing of genes located in heterochromatin regions. Studies highlight its involvement in the three-dimensional organization of the nucleus and the regulation of transcriptional networks. The exploration of SMCHD1 recombinant proteins allows scientists to dissect its functional mechanisms at a molecular level, facilitating the identification of potential therapeutic targets for associated diseases. Furthermore, understanding the structural properties and interaction dynamics of SMCHD1 can shed light on its role within the broader context of epigenetic regulation and chromosomal dynamics. As such, SMCHD1 stands at the intersection of molecular biology, genetics, and potential clinical applications, driving research efforts to elucidate its significance in both normal cellular processes and pathological conditions.
