Analytical Data
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基因名
TMTC1
- Application
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别名
TMTC1; ARG99; Protein O-mannosyl-transferase TMTC1; EC 2.4.1.109; Transmembrane and TPR repeat-containing Protein 1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8IUR5
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表达区间
1-774 aa
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氨基酸序列
MNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAFLSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPHRENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKEVLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIVSTVLLLLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRLAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDSKLLKENLAKLDRLEKRLQEVREKDQT
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分子量
113.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TMTC1 (Transmembrane and Tetratricopeptide Repeats 1) is a protein that has garnered significant attention in recent years due to its involvement in various cellular processes and potential implications in disease pathogenesis. Initially identified as a transmembrane protein, TMTC1 is thought to function within the endoplasmic reticulum (ER) and play a role in protein folding and trafficking. Research has highlighted its crucial role in the maintenance of cellular calcium homeostasis and its potential influence on neurodevelopmental disorders, particularly because mutations in the TMTC1 gene have been linked to syndromic conditions affecting the nervous system. Additionally, the study of TMTC1 as a recombinant protein offers valuable insights into its functional dynamics and interactions within cellular environments. By producing and characterizing TMTC1 in a controlled setting, researchers can dissect its structural properties, elucidate its biochemical pathways, and explore its interactions with other proteins. Understanding the role of TMTC1 at a molecular level not only sheds light on basic cellular biology but also paves the way for therapeutic strategies targeting malfunctions associated with TMTC1 dysregulation. The ongoing research into TMTC1 recombinant protein represents a promising avenue towards uncovering novel insights into its biological significance and therapeutic potential in related disorders.
