Analytical Data
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基因名
GDF8
- Application
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别名
MSTN. GDF8
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O14793
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表达区间
1-375aa
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氨基酸序列
MQKLQLCVYIYLFMLIVAGPVDLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQILSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIITMPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS
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分子量
69.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GDF8, also known as myostatin, is a member of the transforming growth factor-beta (TGF-β) superfamily and plays a critical role in the regulation of skeletal muscle growth and development. Initially identified in cattle as a gene responsible for muscle hypertrophy when mutated, GDF8's importance has been extensively studied in both animal models and humans. Myostatin acts primarily as a negative regulator of muscle mass, inhibiting myoblast proliferation and differentiation, and thereby controlling muscle fiber development and growth. Understanding the mechanisms through which GDF8 operates has significant implications for muscle-wasting diseases, obesity, and age-related muscle loss. The recombinant form of GDF8 is increasingly being utilized in research to investigate its signaling pathways and interactions in various cellular contexts. It has the potential to serve as a therapeutic target for conditions characterized by muscle atrophy, such as muscular dystrophies and cachexia. Recent advancements in recombinant protein production have allowed for the generation of high-purity GDF8, facilitating detailed biochemical assays and in vivo studies. Researchers are exploring strategies to modulate GDF8 activity, aiming to enhance muscle regeneration and overall metabolic health. The ongoing research into GDF8 and its recombinant protein could provide groundbreaking insights into muscle biology and innovative therapeutic approaches for muscle-related disorders.
