Analytical Data
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Gene name
PC4/SUB1
- Application
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Alternative Names
Positive cofactor 4 ;PC4SUB1 homologp14
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P53999
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Expression Region
2-127aa
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Molecular Weight
30.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The PC4/SUB1 protein, initially identified as a factor involved in the regulation of gene expression in yeast, has garnered significant attention in recent years due to its multifaceted roles in various biological processes. This protein is known to participate in DNA repair, transcription regulation, and cellular responses to stress, making it a crucial player in maintaining genomic stability and proper cellular function. Studies have revealed that PC4/SUB1 can interact with a variety of proteins and DNA elements, influencing the transcriptional machinery and facilitating the recruitment of RNA polymerase II to specific gene promoters. Furthermore, its involvement in the cellular response to environmental stimuli highlights its potential relevance in cancer biology and other diseases where gene regulation is disrupted. The characterization of PC4/SUB1 as a nuclear protein involved in the assembly of transcription complexes has opened new avenues for understanding how eukaryotic cells regulate gene expression under diverse conditions. Given its pivotal role, ongoing research seeks to elucidate the molecular mechanisms governing PC4/SUB1 function and its implications in cellular processes, which could lead to novel therapeutic strategies targeting related pathways in human diseases.
