Analytical Data
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基因名
PC4/SUB1
- Application
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别名
Positive cofactor 4 ;PC4SUB1 homologp14
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P53999
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表达区间
2-127aa
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分子量
30.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The PC4/SUB1 protein, initially identified as a factor involved in the regulation of gene expression in yeast, has garnered significant attention in recent years due to its multifaceted roles in various biological processes. This protein is known to participate in DNA repair, transcription regulation, and cellular responses to stress, making it a crucial player in maintaining genomic stability and proper cellular function. Studies have revealed that PC4/SUB1 can interact with a variety of proteins and DNA elements, influencing the transcriptional machinery and facilitating the recruitment of RNA polymerase II to specific gene promoters. Furthermore, its involvement in the cellular response to environmental stimuli highlights its potential relevance in cancer biology and other diseases where gene regulation is disrupted. The characterization of PC4/SUB1 as a nuclear protein involved in the assembly of transcription complexes has opened new avenues for understanding how eukaryotic cells regulate gene expression under diverse conditions. Given its pivotal role, ongoing research seeks to elucidate the molecular mechanisms governing PC4/SUB1 function and its implications in cellular processes, which could lead to novel therapeutic strategies targeting related pathways in human diseases.
