Analytical Data
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Gene name
CRELD2
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简介
CRELD2 Protein, potentially acting as a protein disulfide isomerase, may play a role in the unfolded protein response. It is also implicated in regulating the transport of the alpha4-beta2 neuronal acetylcholine receptor, showcasing its versatility in cellular processes related to protein folding and neuronal receptor dynamics. These functions suggest CRELD2's involvement in maintaining cellular homeostasis. CRELD2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CRELD2 protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Alternative Names
Cysteine-Rich With EGF-Like Domain Protein 2; CRELD2
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Species
Mouse
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9CYA0
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Expression Region
S23-L350
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Protein Length
Full Length of Mature Protein
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CRELD2 (Cysteine-Rich with EGF-Like Domain 2) is a member of theCRELD family of proteins, which are known to play critical roles in developmental processes and extracellular matrix regulation. This protein has garnered attention due to its implications in various pathophysiological conditions, particularly in relation to cardiovascular development and congenital heart defects. Research indicates that CRELD2 is involved in the formation of heart structures during embryogenesis, making it a potential biomarker for heart-related abnormalities. Recent studies focusing on the recombinant expression of CRELD2 have aimed at elucidating its functional roles and mechanisms at the molecular level. Generation of recombinant CRELD2 proteins allows for the investigation of its interactions with other cellular proteins and extracellular matrix components, providing insights into its biological relevance. Moreover, understanding the structure-function relationship of CRELD2 may reveal potential therapeutic targets for treating cardiovascular diseases. As such, the study of CRELD2 recombinantly is crucial for advancing our knowledge of its role in developmental biology and its potential applications in regenerative medicine and disease modeling.
