Analytical Data
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基因名
NGL-1/LRRC4C
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简介
NGL-1/LRRC4C protein promotes neurite outgrowth in thalamic neurons, shaping neural circuit architecture. It interacts with NTNG1 and WHRN to modulate neurite outgrowth and synaptic connections. Investigating its mechanisms and downstream effects could provide insights into its role in neural development and circuit formation. NGL-1/LRRC4C Protein, Mouse (HEK293, His) is the recombinant mouse-derived NGL-1/LRRC4C protein, expressed by HEK293 , with C-His labeled tag.
- Application
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别名
Leucine-rich repeat-containing protein 4C; Netrin-G1 ligand; KIAA1580; NGL1
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种属
Mouse
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表达系统
HEK293
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标签
C-10*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8C031
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表达区间
Q45-K527
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氨基酸序列
QTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLSWWIRDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTCYAPVIVEPPADLNVTEGMAAELKCRASTSLTSVSWITPNGTVMTHGAYKVRIAVLSDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASATLNVTAATTTPFSYFSTVTVETMEPSQDEARTTDNNVGPTPVIDWETTNVTTSLTPQSTRSTEKTFTIPVTDINSGIPGIDEVMKTTK
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蛋白长度
Partial
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分子量
95-115 kDa.
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NGL-1 (Neuronal Growth Regulator 1) and LRRC4C (Leucine-Rich Repeat Containing 4C) are two proteins implicated in the regulation of neuronal development and synaptic plasticity. NGL-1 is known to play a critical role in promoting excitatory synapse formation by interacting with various proteins involved in synapse maturation, while LRRC4C is thought to function as an auxiliary subunit that modulates receptor activity, specifically those of AMPA-type glutamate receptors. The study of NGL-1/LRRC4C recombinant proteins has gained significance in understanding the molecular mechanisms underlying synaptic transmission and neural network formation. Recent advances in structural biology and biochemistry have enabled researchers to produce these proteins in recombinant form, allowing for detailed analysis of their interactions and functional characteristics. Examining the recombinant NGL-1/LRRC4C proteins can provide insights into their roles in both normal physiology and pathological conditions such as neurodevelopmental disorders and neurodegenerative diseases. By elucidating the mechanisms by which these proteins influence neuronal connectivity and synaptic efficacy, researchers aim to pave the way for novel therapeutic strategies aimed at enhancing synaptic function and mitigating the effects of neurological diseases. Overall, the investigation of NGL-1 and LRRC4C at the protein level is crucial for a deeper understanding of synaptic biology and its impact on cognitive function.
