Analytical Data
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Gene name
TAFA5/FAM19A5
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简介
As a chemokine-like molecule, TAFA5/FAM19A5 protein activates GPCRs such as S1PR2 and FPR2 to regulate cell proliferation and migration. It induces macrophage chemotactic migration through MAPK3/ERK1 and AKT1 pathways and inhibits TNFSF11/RANKL-induced osteoclast formation. TAFA5/FAM19A5 Protein, Mouse (His) is the recombinant mouse-derived TAFA5/FAM19A5 protein, expressed by E. coli , with N-His labeled tag.
- Application
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Alternative Names
Chemokine-like protein TAFA-5; Tafa5; Fam19a5; QLLK5208; UNQ5208
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Species
Mouse
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Source
E. coli
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Tag
N-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q91WE9-1
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Expression Region
T44-S132
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Protein Length
Full Length of Isoform-1 Mature Protein
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Molecular Weight
13-14 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TAFA5, also known as FAM19A5, belongs to the TAFA family of proteins that are characterized by their unique structural features and potential roles in immune modulation. Recent studies have highlighted the importance of the TAFA family in inflammatory processes, suggesting that these proteins may play critical roles in the regulation of immune responses and the pathogenesis of various diseases. Specifically, TAFA5 has garnered attention due to its differential expression in various tissues and its implications in neurological health and disorders. Researchers are investigating the recombinant expression of TAFA5/FAM19A5 to better understand its biological functions and mechanisms of action. The successful production of recombinant TAFA5 enables detailed functional studies, including investigations into its receptor interactions, signaling pathways, and potential therapeutic applications. Given its potential role in modulating immune responses, TAFA5 could be a valuable target for developing novel treatments for inflammatory and neurodegenerative diseases.
