Analytical Data
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Gene name
RAB5B
- Application
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Alternative Names
RAB5B; Ras-related protein Rab-5B
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Species
Human
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P61020
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Expression Region
1-215aa
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Molecular Weight
50.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RAB5B, a member of the RAB family of small GTPases, plays a crucial role in the early stages of endocytosis and the regulation of membrane trafficking within cells. It is primarily localized to early endosomes and regulates various cellular processes such as signal transduction, nutrient uptake, and the recycling of membrane proteins. The study of RAB5B has gained significant attention due to its involvement in numerous biological functions and its potential implications in various diseases, including cancer, neurodegenerative disorders, and infections. Recombination techniques have enabled the production of RAB5B recombinant proteins, which are essential for understanding its functional mechanisms, interactions with effector proteins, and role in pathological conditions. Research involving RAB5B recombinant proteins provides insights into the dynamics of endosomal trafficking and its impact on cellular homeostasis. Moreover, the examination of RAB5B in the context of disease states may unveil novel therapeutic targets, making it a vital protein of interest in cell biology and medicine. Overall, the exploration of RAB5B through recombinant protein studies not only enhances our understanding of intracellular transport processes but also paves the way for potential clinical applications.
