Analytical Data
-
Gene name
AKR1C1
- Application
-
Alternative Names
AKR1C1；DDH；DDH1；Aldo-keto reductase family 1 member C1
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q04828
-
Expression Region
1-323aa
-
AA Sequence
MDSKHQCVKL NDGHFMPVLG FGTYAPAEVP KNKAIEATKL AIEAGFRHID SAHLYNNEEY VGLAIRSKIA DGTVKREDIF YTSKLWCNSH RPEFVRPALE RSLKNLQLDY VDLYLIHFPV SLKPGEELIP KDENGKLLFD TVDLCATWEA MEKCKDAGLA KSIGVSNFNR RQLEMILNKP GLKYKPVCNQ VECHPYLNQR KLLDFCKSKD IVLVAYSALG SHREKPWVDQ NSPVLLEDPV LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIREN MKVFEFQLTS EDMKAIDGLD RNIRYLTLDI FAGPPNYPFS DEY
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
AKR1C1, also known as aldo-keto reductase 1C1, is a member of the aldo-keto reductase superfamily that plays a crucial role in the metabolism of endogenous and exogenous compounds, including steroid hormones, prostaglandins, and xenobiotics. The enzyme is involved in the reduction of aldehydes and ketones to their corresponding alcohols, thereby influencing various physiological processes such as steroid biosynthesis and the regulation of inflammation. Dysregulation of AKR1C1 has been implicated in several diseases, including cancer, obesity, and metabolic disorders, sparking interest in its potential as a therapeutic target. Research on recombinant AKR1C1 protein has primarily focused on understanding its structural and functional characteristics, enzymatic mechanisms, and its interactions with different substrates and inhibitors. Advances in recombinant DNA technology have allowed for the production of purified AKR1C1, facilitating detailed kinetic studies and enabling high-throughput screening of small molecules that may modulate its activity. Furthermore, understanding the role of AKR1C1 in drug metabolism can inform the development of more effective pharmacological interventions and personalized medicine approaches. As such, AKR1C1 remains a significant area of research within biochemistry and pharmacology, with ongoing studies aimed at elucidating its full biological function and therapeutic potential.
