Analytical Data
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Gene name
CD5
- Application
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Alternative Names
CD5；LEU1；T-cell surface glycoProtein CD5
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P06127
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Expression Region
25-372aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSRLSWYDP DFQARLTRSN SKCQGQLEVY LKDGWHMVCS QSWGRSSKQW EDPSQASKVC QRLNCGVPLS LGPFLVTYTP QSSIICYGQL GSFSNCSHSR NDMCHSLGLT CLEPQKTTPP TTRPPPTTTP EPTAPPRLQL VAQSGGQHCA GVVEFYSGSL GGTISYEAQD KTQDLENFLC NNLQCGSFLK HLPETEAGRA QDPGEPREHQ PLPIQWKIQN SSCTSLEHCF RKIKPQKSGR VLALLCSGFQ PKVQSRLVGG SSICEGTVEV RQGAQWAALC DSSSARSSLR WEEVCREQQC GSVNSYRVLD AGDPTSRGLF CPHQKLSQCH ELWERNSYCK KVFVTCQDPN P
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Molecular Weight
41 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CD5 is a glycoprotein expressed predominantly on the surface of T lymphocytes and a subset of B cells, playing a crucial role in immune regulation and T cell activation. Research into CD5 has gained significant attention due to its involvement in various physiological and pathological processes, including autoimmune diseases, infections, and cancer. CD5 is known to modulate T cell receptor (TCR) signaling, acting as a negative regulator that can alter the strength and duration of T cell responses. This intriguing property makes CD5 an important target for therapeutic interventions aimed at enhancing immune responses in cancer therapies or dampening excessive responses in autoimmune conditions. Recombinant CD5 proteins have been developed to better understand its functional mechanisms and potential as a biomarker. These studies aim to elucidate the molecular pathways influenced by CD5 and explore its interactions with other immune components. By employing advanced techniques such as gene editing and protein engineering, researchers are investigating the role of CD5 in T cell differentiation, homeostasis, and survival. The insights gained from these studies are expected to pave the way for novel immunotherapeutic strategies and improve our understanding of the immune system's complexity. In summary, the exploration of recombinant CD5 proteins represents a vital avenue for advancing immunology research and developing targeted therapies for related diseases.
