Analytical Data
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基因名
CLEC4E
- Application
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别名
CLEC4E；CLECSF9；MINCLE；C-type lectin domain family 4 member E
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9ULY5
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表达区间
41-219aa
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氨基酸序列
RCVVTFRIFQTCDEKKFQLPENFTELSCYNYGSGSVKNCCPLNWEYFQSS CYFFSTDTISWALSLKNCSAMGAHLVVINSQEEQEFLSYKKPKMREFFIG LSDQVVEGQWQWVDGTPLTKSLSFWDVGEPNNIATLEDCATMRDSSNPRQ NWNDVTCFLNYFRICEMVGINPLNKGKSLVDHHHHHH
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分子量
22 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CLEC4E, also known as DC-SIGNR (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Nonintegrin), is a C-type lectin receptor predominantly expressed in dendritic cells and macrophages. It plays a crucial role in the immune system by recognizing and binding to various pathogens, including viruses, bacteria, and parasites, which facilitates their uptake and presentation to T cells. This mechanism is vital for initiating adaptive immune responses. Recent studies have highlighted the importance of CLEC4E in mediating infections, notably with viruses like HIV and Ebola, as it can serve as a viral entry receptor. Moreover, CLEC4E's role in modulating immune responses has garnered attention for its potential implications in autoimmune diseases and cancer immunotherapy. Understanding the structure and function of CLEC4E can lead to novel therapeutic strategies, including vaccine development and targeted treatments. Researchers are now focusing on elucidating the molecular mechanisms underlying its interactions with pathogens and exploring its potential as a biomarker for various diseases. This research is critical for advancing our knowledge of immune defense mechanisms and developing innovative approaches to combat infectious diseases and promote better health outcomes.
