Analytical Data
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基因名
Rab5a
- Application
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别名
RAB5A;RAB5;Ras-related Protein Rab-5A
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P20339
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表达区间
1-215aa
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氨基酸序列
MASRGATRPNGPNTGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQASPNIVIALSGNKADLANKRAVDFQEAQSYADDNSLLFMETSAKTSMNVNEIFMAIAKKLPKNEPQNPGANSARGRGVDLTEPTQPTRNQCCSN
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分子量
39.7kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Rab5a is a member of the Rab GTPase family, which plays a crucial role in regulating membrane trafficking and endocytic pathways in eukaryotic cells. Research into Rab5a has gained momentum due to its significant involvement in various cellular processes, including early endosome formation, fusion, and the regulation of endocytosis. Dysregulation of Rab5a has been linked to several diseases, including neurodegenerative disorders and cancer, highlighting its potential as a therapeutic target. The study of Rab5a recombinant proteins is essential for understanding its functional mechanisms and interactions within cellular pathways. By generating and characterizing these proteins, researchers can elucidate the molecular dynamics of Rab5a in endosome maturation and its influence on signaling pathways. Furthermore, the exploration of Rab5a's interactions with other proteins and its role in the cellular context may provide insights into the development of novel therapeutic strategies to modulate its activity in disease states. Given the increasing interest in membrane trafficking and cellular homeostasis, Rab5a remains a prominent focal point in cell biology research, underscoring the importance of recombinant protein studies in this domain.
