Analytical Data
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基因名
HAase
- Application
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别名
HAase；KIAA1788；Homeobox Protein aristaless-like 4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H161
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表达区间
1-411aa
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氨基酸序列
MNAETCVSYCESPAAAMDAYYSPVSQSREGSSPFRAFPGGDKFGTTFLSAAAKAQGFGDAKSRARYGAGQQDLATPLESGAGARGSFNKFQPQPSTPQPQPPPQPQPQQQQPQPQPPAQPHLYLQRGACKTPPDGSLKLQEGSSGHSAALQVPCYAKESSLGEPELPPDSDTVGMDSSYLSVKEAGVKGPQDRASSDLPSPLEKADSESNKGKKRRNRTTFTSYQLEELEKVFQKTHYPDVYAREQLAMRTDLTEARVQVWFQNRRAKWRKRERFGQMQQVRTHFSTAYELPLLTRAENYAQIQNPSWLGNNGAASPVPACVVPCDPVPACMSPHAHPPGSGASSVTDFLSVSGAGSHVGQTHMGSLFGAASLSPGLNGYELNGEPDRKTSSIAALRMKAKEHSAAISWAT
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分子量
44.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HAase, or Hyaluronidase, is an enzyme that plays a crucial role in the degradation of hyaluronic acid, a significant component of the extracellular matrix. Research into HAase recombinant proteins has gained momentum due to their potential therapeutic applications in various medical fields, including oncology, dermatology, and regenerative medicine. Hyaluronic acid is vital for tissue hydration, proliferation, and migration, making HAase instrumental in promoting the bioavailability of drugs and enhancing tissue permeability. The production of recombinant HAase allows for a more controlled and efficient source of the enzyme compared to traditional extraction methods, which may yield variable results due to the heterogeneous nature of natural sources. Advances in genetic engineering and fermentation technologies facilitate large-scale production and purification of HAase, enhancing its application as a therapeutic agent. Recent studies have focused on optimizing HAase for specific activities and improving its stability and efficacy in various biological environments. Consequently, the investigation of HAase recombinant proteins not only contributes to understanding the biological roles of hyaluronidase but also paves the way for innovative treatments that harness its enzymatic properties to modulate tissue dynamics and enhance drug delivery systems. The ongoing exploration of HAase highlights its significance as a biopharmaceutical and its promise in advancing personalized medicine approaches.
