Analytical Data
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基因名
RGS4
- Application
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别名
RGS4;Regulator of G-Protein signaling 4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P49798
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表达区间
1-205aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMCKGLAGLPASCLRSAKDMKHRLGFLLQKS DSCEHNSSHNKKDKVVIC QRVSQEEVKKWAESLENLISHECGLAAFKA FLKSEYSEENIDFWISCEEYKKIKSPSKLSPKAKKIYNEFISVQA TKE VNLDSCTREETSRNMLEPTITCFDEAQKKIFNLMEKDSYRRFLKSRFYLD LVNPSSCGAEKQKGAKSSADCA SLVPQCA
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分子量
25 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RGS4 (Regulator of G protein Signaling 4) is a critical member of the RGS protein family, known for its role in regulating G protein-coupled receptor (GPCR) signaling pathways. These pathways are vital for various physiological processes, including neurotransmission, cell proliferation, and cardiovascular function. Dysregulation of RGS4 has been implicated in several psychiatric disorders and cardiovascular diseases, making it an important target for therapeutic intervention. Research into RGS4 recombinant proteins has gained momentum as these proteins facilitate the study of RGS4's structure, function, and interactions with G proteins and receptors. By producing RGS4 in a recombinant form, scientists can elucidate its precise mechanisms of action, assess its functional properties, and explore its potential as a drug target. Studies utilizing RGS4 recombinant proteins have also contributed to understanding how RGS4 influences GPCR signaling dynamics and offers insights into developing novel molecules that could modulate these pathways for therapeutic benefits. In particular, the characterization of RGS4's interactions at the molecular level opens new avenues for drug discovery that may lead to more effective treatments for diseases linked to GPCR dysregulation. Overall, the investigation of RGS4 recombinant proteins is a promising field that merges basic biochemistry with clinical potential, highlighting the significance of RGS4 in both health and disease.
