Analytical Data
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Gene name
NDRG4
- Application
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Alternative Names
BDM1; Brain development-related molecule 1; KIAA1180; Ndrg4; NDRG4_HUMAN; Protein NDRG4; SMAP 8; SMAP-8; Vascular smooth muscle cell-associated protein 8
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9ULP0
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Expression Region
1-352 aa
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AA Sequence
MPECWDGEHD IETPYGLLHV VIRGSPKGNR PAILTYHDVG LNHKLCFNTF FNFEDMQEIT KHFVVCHVDA PGQQVGASQF PQGYQFPSME QLAAMLPSVV QHFGFKYVIG IGVGAGAYVL AKFALIFPDL VEGLVLVNID PNGKGWIDWA ATKLSGLTST LPDTVLSHLF SQEELVNNTE LVQSYRQQIG NVVNQANLQL FWNMYNSRRD LDINRPGTVP NAKTLRCPVM LVVGDNAPAE DGVVECNSKL DPTTTTFLKM ADSGGLPQVT QPGKLTEAFK YFLQGMGYIA YLKDRRLSGG AVPSASMTRL ARSRTASLTS ASSVDGSRPQ ACTHSESSEG LGQVNHTMEV SC
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Molecular Weight
38.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NDRG4 (N-Myc downstream-regulated gene 4) is a member of the NDRG family of proteins, known to play crucial roles in cellular processes such as differentiation, proliferation, and stress response. Emerging research has implicated NDRG4 in various pathological states, notably in cancer, where its expression is often correlated with tumor progression and patient prognosis. The protein is considered a potential biomarker for certain malignancies, with studies suggesting its involvement in regulating tumor cell metabolism and apoptosis. Additionally, NDRG4 has been linked to neurodegenerative diseases, highlighting its significance beyond cancer. The recombinant protein of NDRG4 has gained attention for its application in therapeutic research and as a potential drug target, offering insights into the molecular mechanisms underlying its functions. By studying NDRG4, researchers aim to unravel its role in disease pathways, providing avenues for novel treatment strategies. Understanding its structure-function relationships through recombinant methods enables the exploration of its potential interactions with other proteins and cellular components, paving the way for advancements in targeted therapies. Thus, the investigation of NDRG4 recombinant protein not only enhances our knowledge of its biological significance but also opens new frontiers in medical research aimed at addressing critical health challenges.
