Analytical Data
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Gene name
ALDH8A1
- Application
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Alternative Names
ALDH8A1; ALDH122-aminomuconic semialdehyde dehydrogenase; EC 1.2.1.32
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H2A2
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Expression Region
1-487aa
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AA Sequence
MAGTNALLML ENFIDGKFLP CSSYIDSYDP STGEVYCRVP NSGKDEIEAA VKAAREAFPS WSSRSPQERS RVLNQVADLL EQSLEEFAQA ESKDQGKTLA LARTMDIPRS VQNFRFFASS SLHHTSECTQ MDHLGCMHYT VRAPVGVAGL ISPWNLPLYL LTWKIAPAMA AGNTVIAKPS ELTSVTAWML CKLLDKAGVP PGVVNIVFGT GPRVGEALVS HPEVPLISFT GSQPTAERIT QLSAPHCKKL SLELGGKNPA IIFEDANLDE CIPATVRSSF ANQGEICLCT SRIFVQKSIY SEFLKRFVEA TRKWKVGIPS DPLVSIGALI SKAHLEKVRS YVKRALAEGA QIWCGEGVDK LSLPARNQAG YFMLPTVITD IKDESCCMTE EIFGPVTCVV PFDSEEEVIE RANNVKYGLA ATVWSSNVGR VHRVAKKLQS GLVWTNCWLI RELNLPFGGM KSSGIGREGA KDSYDFFTEI KTITVKH
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Molecular Weight
79.8 KDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ALDH8A1, or aldehyde dehydrogenase 8 family member A1, is an enzyme that plays a crucial role in the metabolism of various aldehydes, including those derived from neurotransmitters and fatty acids. It is involved in the detoxification of aldehydes, converting them into less harmful carboxylic acids, thus maintaining cellular homeostasis. Research on ALDH8A1 has garnered attention due to its potential implications in numerous physiological processes and pathologies, including neurodegenerative diseases and metabolic disorders. Understanding the structure and function of recombinant ALDH8A1 is essential for elucidating its biological roles and signaling pathways. The production of recombinant ALDH8A1 allows for detailed biochemical studies, including enzyme kinetics, substrate specificity, and inhibition analyses, which are necessary for developing potential therapeutic agents targeting related disorders. Enhanced insights into ALDH8A1’s function could pave the way for novel treatment strategies for diseases linked to aldehyde accumulation, including certain neurodegenerative conditions and cancer. The ongoing characterization of this enzyme may reveal not only its metabolic significance but also its potential as a biomarker for various diseases, further solidifying its relevance in both basic and translational research.
