Analytical Data
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基因名
P2RX4
- Application
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别名
P2RX4；P2X purinoceptor 4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99571
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表达区间
1-388aa
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氨基酸序列
MAGCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSVVSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIPDATTVCKSDASCTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENAGHSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYYRDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYCMKKRLYYREKKYKYVEDYEQGLASELDQ
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分子量
43.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
P2RX4, a member of the P2X receptor family, is an ionotropic receptor activated by extracellular ATP and plays a crucial role in various physiological processes, including neurotransmission, inflammation, and immune responses. The interest in recombinant P2RX4 protein stems from its significance in understanding the molecular mechanisms underlying ATP-mediated signaling pathways. Dysregulation of P2RX4 has been implicated in several pathophysiological conditions, such as neuropathic pain, depression, and respiratory illnesses. As a result, studying P2RX4 can provide insights into disease mechanisms and potential therapeutic targets. Researchers aim to express and purify the recombinant P2RX4 protein for functional analysis, which can involve electrophysiological studies, binding assays, and structural characterization. These studies are essential for elucidating the receptor's role in normal and pathological states and offer the potential for drug development targeting P2RX4. The recombinant protein serves as a valuable tool for further exploration of ATP's role in cellular communication and its implications for health and disease.
