Analytical Data
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基因名
BIN3
- Application
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别名
BIN3Bridging integrator 3
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NQY0
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表达区间
1-253aa
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氨基酸序列
MSWIPFKIGQ PKKQIVPKTV ERDFEREYGK LQQLEEQTRR LQKDMKKSTD ADLAMSKSAV KISLDLLSNP LCEQDQDLLN MVTALDTAMK RMDAFNQEKV NQIQKTVIEP LKKFGSVFPS LNMAVKRREQ ALQDYRRLQA KVEKYEEKEK TGPVLAKLHQ AREELRPVRE DFEAKNRQLL EEMPRFYGSR LDYFQPSFES LIRAQVVYYS EMHKIFGDLS HQLDQPGHSD EQRERENEAK LSELRALSIV ADD
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分子量
29.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BIN3, a member of the BCL-2 family, has garnered significant attention in recent years due to its crucial role in apoptosis and cellular stress responses. Initially identified in the context of cancer biology, BIN3 has been implicated in the regulation of programmed cell death, making it a potential therapeutic target for various malignancies. Research has shown that BIN3 interacts with other pro-apoptotic and anti-apoptotic proteins, influencing the balance between cell survival and death. Additionally, BIN3 has been linked to neurodegenerative disorders, emphasizing its importance beyond cancer. Understanding the structure and function of BIN3, particularly through the study of its recombined protein forms, is essential for elucidating its mechanisms of action in both healthy and diseased states. These studies could pave the way for the development of new treatment strategies aimed at modulating BIN3 activity, offering hope for improved therapies in cancer and neurodegenerative diseases. Moreover, ongoing investigations into the signaling pathways involving BIN3 may reveal broader implications for cellular homeostasis and the response to various stress stimuli. As researchers continue to explore the diverse roles of BIN3, its potential as a biomarker and therapeutic target remains a promising avenue for future scientific inquiry.
