Analytical Data
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基因名
CDKN1B
- Application
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别名
CDKN1B；KIP1；p27；Cyclin-dependent kinase inhibitor 1B
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P46527
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表达区间
1-198aa
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氨基酸序列
MSNVRVSNGS PSLERMDARQ AEHPKPSACR NLFGPVDHEE LTRDLEKHCR DMEEASQRKW NFDFQNHKPL EGKYEWQEVE KGSLPEFYYR PPRPPKGACK VPAQESQDVS GSRPAAPLIG APANSEDTHL VDPKTDPSDS QTGLAEQCAG IRKRPATDDS STQNKRANRT EENVSDGSPN AGSVEQTPKK PGLRRRQT
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分子量
52 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CDKN1B, also known as p27Kip1, is a vital regulator of the cell cycle and a critical component in the control of cellular proliferation. It functions primarily as a cyclin-dependent kinase inhibitor, modulating the activity of cyclin-CDK complexes and thereby influencing cell cycle progression from the G1 phase to the S phase. Dysregulation of CDKN1B expression has been implicated in various cancers, making it a significant focus of cancer research. The recombinant production of the CDKN1B protein serves as a crucial tool for understanding its structural and functional properties, as well as its role in tumorigenesis. Through the generation of a recombinant form of CDKN1B, researchers can study its interactions with cyclins and CDKs, explore its post-translational modifications, and assess its potential as a therapeutic target. Additionally, this recombinant protein can be used in high-throughput screening assays to identify small molecule inhibitors or activators that may influence cell cycle dynamics. Thus, the study of CDKN1B, particularly through its recombinant form, is essential for elucidating its mechanisms in cell cycle regulation, understanding its implications in cancer biology, and developing novel therapeutic strategies.
