Analytical Data
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基因名
RAD51C
- Application
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别名
BROVCA3; DNA repair protein RAD51 homolog 3; FANCO; MGC104277; R51H3; RA51C_HUMAN; Rad 51C; RAD51 homolog C (S. cerevisiae); Rad51 homolog c (S. cerevisiae). isoform CRA_b; RAD51 homolog C; RAD51 like protein 2; RAD51 paralog C; RAD51. S. cerevisiae. homolog of. C; RAD51-like protein 2; RAD51C; RAD51C protein; RAD51L2; RAD51L2/RAD51C protein ; RGD1563765; Yeast RAD51 homolog 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O43502
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表达区间
1-376 aa
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氨基酸序列
MRGKTFRFEM QRDLVSFPLS PAVRVKLVSA GFQTAEELLE VKPSELSKEV GISKAEALET LQIIRRECLT NKPRYAGTSE SHKKCTALEL LEQEHTQGFI ITFCSALDDI LGGGVPLMKT TEICGAPGVG KTQLCMQLAV DVQIPECFGG VAGEAVFIDT EGSFMVDRVV DLATACIQHL QLIAEKHKGE EHRKALEDFT LDNILSHIYY FRCRDYTELL AQVYLLPDFL SEHSKVRLVI VDGIAFPFRH DLDDLSLRTR LLNGLAQQMI SLANNHRLAV ILTNQMTTKI DRNQALLVPA LGESWGHAAT IRLIFHWDRK QRLATLYKSP SQKECTVLFQ IKPQGFRDTV VTSACSLQTE GSLSTRKRSR DPEEEL
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分子量
42.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RAD51L3, a member of the RAD51 family of proteins, plays a crucial role in homologous recombination, a key process for DNA repair and maintenance of genomic stability. The protein is involved in the repair of DNA double-strand breaks and the restart of stalled replication forks, thus preventing genomic instability that can lead to various diseases, including cancer. Research has shown that RAD51L3 interacts with other proteins involved in the DNA damage response, enhancing its function in the homologous recombination pathway. Furthermore, mutations or dysregulation of RAD51L3 have been associated with increased susceptibility to certain cancers, making it a potential biomarker for cancer risk and a target for therapeutic interventions. Understanding the specific mechanisms by which RAD51L3 operates in DNA repair not only sheds light on fundamental cellular processes but also contributes to the development of novel strategies for cancer treatment and prevention. Additionally, studies on RAD51L3 may reveal new insights into the evolution of DNA repair mechanisms across different organisms, highlighting its importance in maintaining genetic integrity.
