Analytical Data
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Gene name
RAI1
- Application
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Alternative Names
Dom 3 homolog Z; DOM 3Z; Dom-3 homolog Z; DOM3 C. elegans homolog of Z; Dom3 homolog Z; DOM3L; Dom3z; DOM3Z_HUMAN; NG6; Protein Dom3Z; RAI1; RAT1-INTERACTING PROTEIN 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O77932
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Expression Region
1-396 aa
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AA Sequence
MDPRGTKRGA EKTEVAEPRN KLPRPAPSLP TDPALYSGPF PFYRRPSELG CFSLDAQRQY HGDARALRYY SPPPTNGPGP NFDLRDGYPD RYQPRDEEVQ ERLDHLLCWL LEHRGRLEGG PGWLAEAIVT WRGHLTKLLT TPYERQEGWQ LAASRFQGTL YLSEVETPNA RAQRLARPPL LRELMYMGYK FEQYMCADKP GSSPDPSGEV NTNVAFCSVL RSRLGSHPLL FSGEVDCTDP QAPSTQPPTC YVELKTSKEM HSPGQWRSFY RHKLLKWWAQ SFLPGVPNVV AGFRNPDGFV SSLKTFPTMK MFEYVRNDRD GWNPSVCMNF CAAFLSFAQS TVVQDDPRLV HLFSWEPGGP VTVSVHQDAP YAFLPIWYVE AMTQDLPSPP KTPSPK
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Molecular Weight
44.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RAI1 (Ring Finger Protein 213) is an essential protein implicated in several biological processes, including transcription regulation and genome stability. Research on RAI1 has gained momentum due to its association with the 14q32 deletion syndrome, which is characterized by developmental delays, intellectual disabilities, and various physical anomalies. The protein's role as a transcriptional regulator suggests that it may influence gene expression critical for normal development. Recent studies have indicated that RAI1 can interact with components of the RNA Polymerase II machinery, further elucidating its function in gene regulation. Furthermore, its involvement in chromatin remodeling and DNA repair mechanisms highlights its potential significance in maintaining genomic integrity. Understanding RAI1's structure and function through recombinant protein studies is crucial for unraveling its precise role in cellular processes and its contribution to disease pathology. By examining the biochemical properties and interactions of RAI1 protein, researchers aim to uncover potential therapeutic targets for conditions linked to its dysregulation. The development of RAI1 recombinant proteins represents a promising avenue for advancing our comprehension of its multifaceted roles in health and disease.
