Analytical Data
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基因名
LMP1
- Application
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别名
LMP1；Lysosome-associated membrane glycoProtein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13114
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表达区间
1-568aa
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氨基酸序列
MESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLENGTYIKDDTIFIKVIVDTSDLPDP
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分子量
64.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LMP1, or Latent Membrane Protein 1, is an oncoprotein encoded by Epstein-Barr Virus (EBV) and plays a critical role in the pathogenesis of EBV-associated tumors, including lymphomas and nasopharyngeal carcinoma. Research on LMP1 has gained significance due to its multifaceted functions in cell signaling, immune evasion, and transformation of host cells. LMP1 mimics CD40, a receptor found on immune cells, activating various downstream signaling pathways that promote cell proliferation, prevent apoptosis, and enhance survival in infected cells. Understanding the mechanisms underlying LMP1’s action can provide insights into the viral life cycle and the development of EBV-associated malignancies. Additionally, LMP1's role in modulating immune responses makes it a candidate for therapeutic intervention. Scientists have utilized recombinant protein technologies to produce LMP1 for various applications, including the development of vaccines and targeted therapies. By studying the structure and function of LMP1, researchers aim to identify potential targets for drug development and improve therapeutic strategies against EBV-related diseases. The enhanced understanding of the protein's interactions within host cells may lead to novel approaches for combating EBV infections and related cancer pathways, making LMP1 a focal point of ongoing research in virology and oncology.
