Analytical Data
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Gene name
C2orf63
- Application
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Alternative Names
CLHC1; C2orf63; Clathrin heavy chain linker domain-containing Protein 1
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8NHS4
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Expression Region
1-586aa
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AA Sequence
MSVHQIRKHAVLPPIICRSDKEFLESVQRYIITETERLGCSEEGPADEYYIIYRNVFDKVIEHITAYKSILTSIKKEYDAFIETIKKDRRTTFCLHGKLKGLAAEPTALVYYRKRTIQLEAKMRIIESNSSKIQSQIDHIKQCRAEYDTKEVKYCTFSKDPSKPIPGMTLQESMNLDALTKYMKHLEDKYAEIKQAMLIKYVPAQRKADLDEEMIVLLKRRDVAENLNKKLQFCHQRLQIISQALSSWVKSDMSSPFQDFVEQIQKTKYLQGDQGIVEELMEDDPRRAKEAEIMLHYIERFNELISLGEYEKAACYAANSPRRILRNIGTMNTFKAVGKIRGKPLPLLLFFEALFITSHAFPCPVDAALTLEGIKCGLSEKRLDLVTNWVTQERLTFSEEAGDVICDYGEQDTYNKAKCLALAQIIYSECGLHKKAILCLCKQGQTHRVMEYIQQLKDFTTDDLLQLLMSCPQVELIQCLTKELNEKQPSLSFGLAILHLFSVDMKKVGIKLLQEINKGGIDAVESLMINDSFCSIEKWQEVANICSQNGFDKLSNDITSILRSQAAVTEISEEDDAVNLMEHVFW
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Molecular Weight
93.7 KDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
C2orf63, also known as chromosome 2 open reading frame 63, is a gene located on chromosome 2 that has garnered attention due to its potential roles in various biological processes and disease mechanisms. Research into C2orf63 has been motivated by its association with certain genetic disorders and conditions, particularly in relation to its expression patterns in human tissues. Studies have suggested that C2orf63 may be involved in cellular signaling, differentiation, and possibly in the maintenance of genome stability. As a relatively understudied protein, its exact function remains largely unknown, but emerging evidence indicates it could play a role in developmental processes and contribute to the understanding of disease pathology, including cancers and inherited disorders. Researchers are increasingly focused on characterizing C2orf63 through recombinant protein expression techniques, which facilitate the production of the protein for functional analysis. These studies aim to elucidate its biochemical properties, interactions with other molecular players, and downstream effects in cellular pathways. Ultimately, greater insight into C2orf63 could not only advance the fundamental understanding of its biological role but may also open new avenues for therapeutic interventions targeting diseases associated with its dysregulation. This growing body of work represents a promising frontier in genetic research and underscores the importance of continuing investigations into under-explored proteins such as C2orf63.
