Analytical Data
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基因名
DUSP14
- Application
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别名
DUSP14；MKP6；Dual specificity Protein phosphatase 14
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95147
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表达区间
1-198aa
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氨基酸序列
MSSRGHSTLPRTLMAPRMISEGDIGGIAQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLFGKSTVKMVQTPYGIVPDVYEKESRHLMPYWGI
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分子量
38.3kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DUSP14, a member of the dual specificity phosphatase (DUSP) family, plays a critical role in cellular signaling by dephosphorylating both tyrosine and serine/threonine residues on its substrates, which include key mitogen-activated protein kinases (MAPKs). The dysregulation of DUSP14 has been implicated in various pathological conditions, including cancer, inflammatory diseases, and neurodegenerative disorders, making it a potential therapeutic target. Research on DUSP14 has gained momentum as scientists seek to elucidate its mechanisms of action in facilitating cellular responses to environmental stimuli. Understanding the structure and function of recombinant DUSP14 protein is essential for dissecting its role in cellular pathways and providing insights into its potential as a biomarker or therapeutic agent. Techniques such as protein expression in heterologous systems, characterization of enzymatic activity, and determination of substrate specificity are crucial for advancing our comprehension of DUSP14's biological functions. By creating recombinant versions of DUSP14, researchers can explore its interactions with MAPKs and other signaling molecules, paving the way for novel therapeutic strategies that leverage the modulation of DUSP14 activity in various diseases.
