Analytical Data
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基因名
RHOH
- Application
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别名
ARHH; GTP binding protein TTF; GTP-binding protein TTF; OTTHUMP00000125213; Ras homolog gene family member H; Rho related GTP binding protein; Rho related GTP binding protein RhoH; Rho-related GTP-binding protein RhoH; RHOH; RHOH_HUMAN; Translocation three four protein; TTF; TTF translocation three four
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q15669
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表达区间
1-188 aa
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氨基酸序列
MLSSIKCVLV GDSAVGKTSL LVRFTSETFP EAYKPTVYEN TGVDVFMDGI QISLGLWDTA GNDAFRSIRP LSYQQADVVL MCYSVANHNS FLNLKNKWIG EIRSNLPCTP VLVVATQTDQ REMGPHRASC VNAMEGKKLA QDVRAKGYLE CSALSNRGVQ QVFECAVRTA VNQARRRNRR RLFSINEC
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分子量
21.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RhoH is a member of the Rho family of small GTPases, which are critical regulators of various cellular processes, including cytoskeletal dynamics, cell proliferation, and apoptosis. Unlike other Rho GTPases, RhoH is uniquely characterized by its inability to bind GTP, leading to its classification as a "GTPase-like protein." This distinctive feature suggests that RhoH primarily functions as a negative regulator of signaling pathways rather than as a traditional GTPase. Research has indicated that RhoH plays a significant role in the immune system, particularly in the development and function of lymphocytes, as well as in cellular interactions within the immune microenvironment. Furthermore, studies have linked RhoH to various hematological malignancies, highlighting its potential as a biomarker and therapeutic target in cancer treatment. Understanding the molecular mechanisms by which RhoH exerts its effects could provide insights into its role in tumorigenesis and immune responses. Given its influence on critical signaling pathways, the investigation of RhoH and its associated pathways presents a promising avenue for developing novel strategies in cancer therapy and immunotherapy. Thus, ongoing research into RhoH's functions and interactions remains essential to unravel its contributions to both normal physiology and disease states.
