Analytical Data
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基因名
RINT1
- Application
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别名
DKFZp667H2324 ; FLJ11785 ; HsRINT 1; HsRINT-1; HsRINT1; RAD50 interacting protein 1 ; RAD50 interactor 1; RAD50-interacting protein 1; RINT 1 ; RINT-1; RINT1; RINT1_HUMAN
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6NUQ1
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表达区间
1-792 aa
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氨基酸序列
MLPAGEIGAS PAAPCCSESG DERKNLEEKS DINVTVLIGS KQVSEGTDNG DLPSYVSAFI EKEVGNDLKS LKKLDKLIEQ RTVSKMQLEE QVLTISSEIP KRIRSALKNA EESKQFLNQF LEQETHLFSA INSHLLTAQP WMDDLGTMIS QIEEIERHLA YLKWISQIEE LSDNIQQYLM TNNVPEAAST LVSMAELDIK LQESSCTHLL GFMRATVKFW HKILKDKLTS DFEEILAQLH WPFIAPPQSQ TVGLSRPASA PEIYSYLETL FCQLLKLQTS DELLTEPKQL PEKYSLPASP SVILPIQVML TPLQKRFRYH FRGNRQTNVL SKPEWYLAQV LMWIGNHTEF LDEKIQPILD KVGSLVNARL EFSRGLMMLV LEKLATDIPC LLYDDNLFCH LVDEVLLFER ELHSVHGYPG TFASCMHILS EETCFQRWLT VERKFALQKM DSMLSSEAAW VSQYKDITDV DEMKVPDCAE TFMTLLLVIT DRYKNLPTAS RKLQFLELQK DLVDDFRIRL TQVMKEETRA SLGFRYCAIL NAVNYISTVL ADWADNVFFL QLQQAALEVF AENNTLSKLQ LGQLASMESS VFDDMINLLE RLKHDMLTRQ VDHVFREVKD AAKLYKKERW LSLPSQSEQA VMSLSSSACP LLLTLRDHLL QLEQQLCFSL FKIFWQMLVE KLDVYIYQEI ILANHFNEGG AAQLQFDMTR NLFPLFSHYC KRPENYFKHI KEACIVLNLN VGSALLLKDV LQSASGQLPA TAALNEVGIY KLAQQDVEIL LNLRTNWPNT GK
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分子量
90.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RINT1 (Regulator of Intercellular Tight Junctions 1) is a protein that has garnered significant interest in the fields of cell biology and molecular genetics due to its critical role in maintaining tight junction integrity and cellular communication. The disruption of RINT1 function has been implicated in various diseases, particularly in cancer, where altered tight junctions contribute to tumor progression and metastasis. Initial studies have highlighted RINT1's involvement in the regulation of vesicular trafficking and its interaction with several key proteins involved in the tight junction complex. Furthermore, its association with signaling pathways that govern cell proliferation and apoptosis underscores its potential as a therapeutic target. Recent advances in recombinant protein technology have enabled the production of RINT1 in sufficient quantities for detailed structural and functional analyses. Understanding the precise mechanisms of RINT1 in cellular processes is essential, as it may reveal novel insights into the molecular basis of diseases linked to tight junction dysfunction. Enhanced knowledge of RINT1's properties could pave the way for innovative approaches in therapeutic interventions, particularly in the context of cancer and other related disorders where tight junction dynamics play a pivotal role. Thus, ongoing research into RINT1 recombinant protein not only aims to elucidate its biological functions but also to explore its potential as a biomarker and therapeutic target in disease contexts.
