Analytical Data
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基因名
CCDC53
- Application
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别名
WASHC3; AD-016; CCDC53; CGI-116; x0009; WASH complex subunit 3; Coiled-coil domain-containing Protein 53
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y3C0
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表达区间
1-194aa
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氨基酸序列
MDEDGLPLMGSGIDLTKVPAIQQKRTVAFLNQFVVHTVQFLNRFSTVCEEKLADLSLRIQQIETTLNILDAKLSSIPGLDDVTVEVSPLNVTSVTNGAHPEATSEQPQQNSTQDSGLQESEVSAENILTVAKDPRYARYLKMVQVGVPVMAIRNKMISEGLDPDLLERPDAPVPDGESEKTVEESSDSESSFSD
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分子量
47.6 KDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CCDC53 (Coiled-Coil Domain Containing 53) is a protein that has gained attention in recent years due to its potential functions in cellular processes and disease mechanisms. Research has indicated that CCDC53 plays a crucial role in cilia formation and maintenance, which are essential for various cellular signaling pathways and developmental processes. Disruptions in cilia function are linked to a range of disorders known as ciliopathies, including Bardet-Biedl syndrome and Joubert syndrome. The importance of CCDC53 in these pathways has spurred interest in studying its structure and function. Recombinant CCDC53 protein can be expressed and purified for detailed biochemical studies, allowing researchers to explore its protein interactions, post-translational modifications, and functional assays. Understanding the molecular mechanisms involving CCDC53 may provide insights into its role in ciliary biology and the pathogenesis of related diseases, ultimately leading to innovative therapeutic strategies. Additionally, the recombinant protein serves as a valuable tool for screening small molecule inhibitors or enhancers that could modulate its function in cellular contexts, contributing to the broader field of drug discovery and development.
