Analytical Data
-
基因名
CDKN1C
- Application
-
别名
Beckwith Wiedemann syndrome; BWCR; BWS; CDKI; CDKN 1C; CDKN1C; CDN1C_HUMAN; Cyclin dependent kinase inhibitor 1C; Cyclin dependent kinase inhibitor p57; Cyclin-dependent kinase inhibitor 1C; Cyclin-dependent kinase inhibitor p57; KIP 2; KIP2; p57; p57 Kip 2; p57KIP2; WBS
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
P49918
-
表达区间
1-316aa
-
氨基酸序列
MSDASLRSTS TMERLVARGT FPVLVRTSAC RSLFGPVDHE ELSRELQARL AELNAEDQNR WDYDFQQDMP LRGPGRLQWT EVDSDSVPAF YRETVQVGRC RLLLAPRPVA VAVAVSPPLE PAAESLDGLE EAPEQLPSVP VPAPASTPPP VPVLAPAPAP APAPVAAPVA APVAVAVLAP APAPAPAPAP APAPVAAPAP APAPAPAPAP APAPAPDAAP QESAEQGANQ GQRGQEPLAD QLHSGISGRP AAGTAAASAN GAAIKKLSGP LISDFFAKRK RSAPEKSSGD VPAPCPSPSA APGVGSVEQT PRKRLR
-
分子量
32.1 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Recombinant E.coli fpaP Protein，His
Cat：PA2000-2958
Recombinant Human LRRTM4 Protein，His
Cat：PA1000-6530
Protein Description
CDKN1C, also known as p57KIP2, is a member of the cyclin-dependent kinase inhibitor (CDKI) family, which plays a crucial role in regulating cell cycle progression. It is located on chromosome 11p15.5 and is imprinted, showing distinctive expression patterns in various tissues. Abnormal expression of CDKN1C has been implicated in several pathologies, including cancer, obesity, and growth disorders such as Beckwith-Wiedemann Syndrome. Research has shown that CDKN1C acts as a tumor suppressor, inhibiting cell proliferation and promoting differentiation. Due to its significant role in cellular regulation, CDKN1C has garnered interest as a potential therapeutic target for controlling tumor growth and progression. However, producing a functional CDKN1C recombinant protein has been challenging, limiting the study of its biochemical properties and potential therapeutic applications. Recent advancements in recombinant protein technology have opened new avenues for the exploration of CDKN1C, enabling researchers to investigate its structural properties, interactions with other proteins, and its mechanism of action in various cellular contexts. Understanding these dynamics is pivotal for developing targeted therapies aimed at restoring the normal function of CDKN1C in diseases associated with its dysfunction.
