Analytical Data
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Gene name
CDKN1C
- Application
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Alternative Names
Beckwith Wiedemann syndrome; BWCR; BWS; CDKI; CDKN 1C; CDKN1C; CDN1C_HUMAN; Cyclin dependent kinase inhibitor 1C; Cyclin dependent kinase inhibitor p57; Cyclin-dependent kinase inhibitor 1C; Cyclin-dependent kinase inhibitor p57; KIP 2; KIP2; p57; p57 Kip 2; p57KIP2; WBS
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P49918
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Expression Region
1-316aa
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AA Sequence
MSDASLRSTS TMERLVARGT FPVLVRTSAC RSLFGPVDHE ELSRELQARL AELNAEDQNR WDYDFQQDMP LRGPGRLQWT EVDSDSVPAF YRETVQVGRC RLLLAPRPVA VAVAVSPPLE PAAESLDGLE EAPEQLPSVP VPAPASTPPP VPVLAPAPAP APAPVAAPVA APVAVAVLAP APAPAPAPAP APAPVAAPAP APAPAPAPAP APAPAPDAAP QESAEQGANQ GQRGQEPLAD QLHSGISGRP AAGTAAASAN GAAIKKLSGP LISDFFAKRK RSAPEKSSGD VPAPCPSPSA APGVGSVEQT PRKRLR
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Molecular Weight
32.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CDKN1C, also known as p57KIP2, is a member of the cyclin-dependent kinase inhibitor (CDKI) family, which plays a crucial role in regulating cell cycle progression. It is located on chromosome 11p15.5 and is imprinted, showing distinctive expression patterns in various tissues. Abnormal expression of CDKN1C has been implicated in several pathologies, including cancer, obesity, and growth disorders such as Beckwith-Wiedemann Syndrome. Research has shown that CDKN1C acts as a tumor suppressor, inhibiting cell proliferation and promoting differentiation. Due to its significant role in cellular regulation, CDKN1C has garnered interest as a potential therapeutic target for controlling tumor growth and progression. However, producing a functional CDKN1C recombinant protein has been challenging, limiting the study of its biochemical properties and potential therapeutic applications. Recent advancements in recombinant protein technology have opened new avenues for the exploration of CDKN1C, enabling researchers to investigate its structural properties, interactions with other proteins, and its mechanism of action in various cellular contexts. Understanding these dynamics is pivotal for developing targeted therapies aimed at restoring the normal function of CDKN1C in diseases associated with its dysfunction.
