Analytical Data
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Gene name
PSMC2
- Application
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Alternative Names
PSMC2；MSS1；26S proteasome regulatory subunit 7
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P35998
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Expression Region
2-433aa
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AA Sequence
PDYLGADQR KTKEDEKDDK PIRALDEGDI ALLKTYGQST YSRQIKQVED DIQQLLKKIN ELTGIKESDT GLAPPALWDL AADKQTLQSE QPLQVARCTK IINADSEDPK YIINVKQFAK FVVDLSDQVA PTDIEEGMRV GVDRNKYQIH IPLPPKIDPT VTMMQVEEKP DVTYSDVGGC KEQIEKLREV VETPLLHPER FVNLGIEPPK GVLLFGPPGT GKTLCARAVA NRTDACFIRV IGSELVQKYV GEGARMVREL FEMARTKKAC LIFFDEIDAI GGARFDDGAG GDNEVQRTML ELINQLDGFD PRGNIKVLMA TNRPDTLDPA LMRPGRLDRK IEFSLPDLEG RTHIFKIHAR SMSVERDIRF ELLARLCPNS TGAEIRSVCT EAGMFAIRAR RKIATEKDFL EAVNKVIKSY AKFSATPRYM TYN
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PSMC2, or Proteasome 26S Subunit ATPase 2, is a critical component of the 26S proteasome, a complex responsible for protein degradation and recycling within eukaryotic cells. The proteasome plays an essential role in maintaining cellular homeostasis by regulating the concentration of specific proteins, thus influencing various cellular processes such as cell cycle progression, signal transduction, and apoptosis. Dysregulation of proteasomal function has been implicated in several diseases, including cancer and neurodegenerative disorders. Research into PSMC2, particularly its role in the ATPase activity and substrate recognition of the proteasome, has garnered significant attention owing to its potential implications in therapeutic interventions. Studies have suggested that PSMC2 is not only vital for proteasome stability but also involved in the modulation of oncogenic pathways, making it a target of interest in cancer biology. Moreover, understanding the structural and functional dynamics of PSMC2 could reveal novel strategies for enhancing proteasomal activity or developing inhibitors that could selectively target proteasome dysfunction in disease contexts. This underscores the importance of ongoing research to elucidate the mechanisms by which PSMC2 contributes to proteasome function and its broader implications in health and disease.
