Analytical Data
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Gene name
MAP1LC3C
- Application
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Alternative Names
MAP1LC3C；NDP52；Calcium-binding and coiled-coil domain-containing Protein 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BXW4
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Expression Region
1-126aa
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AA Sequence
MPPPQKIPSVRPFKQRKSLAIRQEEVAGIRAKFPNKIPVVVERYPRETFLPPLDKTKFLVPQELTMTQFLSIIRSRMVLRATEAFYLLVNNKSLVSMSATMAEIYRDYKDEDGFVYMTYASQETFG
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Molecular Weight
20.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MAP1LC3C, a member of the LC3 (light chain 3) family, is a crucial protein involved in autophagy, a cellular process that degrades and recycles cellular components. As a microtubule-associated protein, MAP1LC3C plays a significant role in the formation and maturation of autophagosomes, which are essential for the degradation of damaged organelles and misfolded proteins. Research has shown that MAP1LC3C is not only essential for maintaining cellular homeostasis but also actively participates in various cellular responses to stress and nutrient deprivation. Abnormalities in MAP1LC3C expression or function have been linked to several diseases, including neurodegenerative disorders, cancer, and infections, rendering it a significant target for therapeutic interventions. The study of MAP1LC3C, particularly through the use of recombinant protein techniques, enables researchers to investigate its specific roles in autophagy and other cellular processes, potentially leading to new insights in disease mechanisms and treatment strategies. Understanding the molecular dynamics of MAP1LC3C and its interactions with other autophagy-related proteins could pave the way for the development of innovative approaches to enhance autophagic flux and ameliorate pathological conditions associated with impaired autophagy.
