Analytical Data
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Gene name
APOBEC3C
- Application
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Alternative Names
APOBEC3C；APOBEC1L；PBI；DNA dC->dU-editing enzyme APOBEC-3C
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NRW3
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Expression Region
1-190aa
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AA Sequence
MNPQIRNPMKAMYPGTFYFQFKNLWEANDRDETWLCFTVEGIKRRSVVSWKTGVFRNQVDSETHCHAERCFLSWFCDDILSPNTKYQVTWYTSWSPCPDCAGEVAEFLARHSNVNLTIFTARLYYFQYPCYQEGLRSLSQEGVAVEIMDYEDFKYCWENFVYNDNEPFKPWKGLKTNFRLLKRRLRESLQ
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Molecular Weight
49.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
APOBEC3C is a member of the APOBEC family of cytidine deaminases, primarily known for its role in the innate immune response against retroviruses, including HIV-1. Research into APOBEC3C has gained momentum due to its ability to induce hypermutation in viral genomes, a mechanism that can inhibit viral replication and contribute to the host's antiviral defense. Unlike other APOBEC proteins, APOBEC3C exhibits a unique ability to target specific DNA sequences, which raises the intrigue surrounding its potential applications in gene editing and therapeutic strategies against viral infections and cancer. Scientists have focused on elucidating the structural and functional dynamics of APOBEC3C, probing its enzymatic activity, stability, and interaction with viral components. Understanding these characteristics could shed light on the protein's role in the evolutionary arms race between viruses and host defenses, as well as its potential for biotechnological innovations. As research advances, it becomes increasingly clear that exploiting APOBEC3C's unique properties could pave the way for novel antiviral therapies and cancer treatments, making it a significant subject of study within molecular biology and virology.
