Analytical Data
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基因名
Notch 4
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简介
Notch 4 protein is a receptor for the ligands JAG1, JAG2 and DLL1 and is responsible for coordinating cell fate decisions.Upon ligand activation, NICD forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes in the cleavage site enhancer.Notch 4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Notch 4 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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别名
Notch4; Int-3; Int3; Notch-4;
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种属
Mouse
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表达系统
HEK293
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标签
C-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P31695
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表达区间
E1042-L1441
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蛋白长度
Partial
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分子量
50-60 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Notch signaling plays a crucial role in various biological processes, including cell differentiation, proliferation, and apoptosis. The Notch pathway is highly conserved across species and is essential for proper development and tissue homeostasis. Notch receptors and their ligands interact to regulate gene expression and influence cell fate decisions. The Notch 4 receptor, one of the five Notch family members, is particularly important in vascular biology and the immune system. Abnormal Notch 4 signaling has been implicated in several diseases, including cancer and cardiovascular conditions. Consequently, understanding the functionalities and mechanisms of Notch 4 is vital for elucidating its role in health and disease. Research on Notch 4 recombinant proteins aims to explore their structure, binding interactions, and downstream signaling pathways. These studies can provide insights into the receptor's specific functions and its potential implications in therapeutic strategies. Furthermore, investigating Notch 4's role in cell fate determination and its impact on tumor microenvironments may unveil new opportunities for targeted interventions in related diseases. By elucidating the signaling cascades and cellular responses governed by Notch 4, researchers hope to advance the understanding of its contributions to both normal physiology and pathophysiological conditions, paving the way for novel therapeutic approaches.
