Analytical Data
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基因名
Siglec-1/CD169
- Application
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别名
CD169; SIGLEC1; Sialic Acid Binding Ig Like Lectin 1
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
Q9BZZ2
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表达区间
Gly34~Gly240
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分子量
26kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Siglec-1, also known as CD169, is a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family, primarily expressed on macrophages and dendritic cells. It plays a crucial role in the immune system by facilitating the recognition and internalization of sialylated pathogens, thus influencing immune responses. The study of Siglec-1/CD169 has gained significant attention due to its potential applications in immunotherapy and vaccine development. Research indicates that this receptor not only participates in pathogen recognition but also modulates the interaction between immune cells and tumor microenvironments. Understanding the structural features and function of Siglec-1/CD169 through recombinant protein studies can provide insights into its role in immune regulation and its potential as a biomarker for certain diseases. Furthermore, the ability to produce recombinant Siglec-1/CD169 protein allows for the exploration of its binding affinities and therapeutic efficacy in various contexts, such as enhancing vaccine responses or targeting tumor cells. The ongoing research aims to unravel the complexities of Siglec-1/CD169 interactions and its implications in both innate and adaptive immunity, positioning it as a promising target for future therapeutic strategies. Through these investigations, scientists hope to harness the mechanisms of Siglec-1/CD169 to improve disease outcome and develop innovative approaches to combat infections and cancer.












