Analytical Data
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Gene name
Siglec-11
- Application
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Biological Activity
Measured by its binding ability in a functional ELISA. When Recombinant Human Siglec-11 Protein is immobilized at 2 µg/mL (100 µL/well) can bind Biotinylated Human Siglec-15 Protein. The ED50 for this effect is 0.975 μg/mL. Measured by its binding ability in a functional ELISA. When Recombinant Human Siglec-11 Protein is immobilized at 2 µg/mL (100 µL/well) can bind Biotinylated Human Siglec-15 Protein. The ED50 for this effect is 0.975 μg/mL.
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Alternative Names
Sialic acid-binding Ig-like lectin 11; SIGLEC11; Sialic acid-binding lectin 11; Siglec-11; Sialic Acid Binding Ig-like Lectin 11
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Species
Human
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Source
CHO
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Tag
C-hFc
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
AAK72907
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Expression Region
N17-H543, E84A, K145Q
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AA Sequence
NKDPSYSLQVQRQVPVPEGLCVIVSCNLSYPRDGWDESTAAYGYWFKGRTSPKTGAPVATNNQSREVAMSTRDRFQLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTQKPDVYIPETLEPGQPVTVICVFNWAFKKCPAPSFSWTGAALSPRRTRPSTSHFSVLSFTPSPQDHDTDLTCHVDFSRKGVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCVTHSSPPARLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQHPLGSQHVSLSLSVHYPPQLLGPSCSWEAEGLHCSCSSQASPAPSLRWWLGEELLEGNSSQGSFEVTPSSAGPWANSSLSLHGGLSSGLRLRCKAWNVHGAQSGSVFQLLPGKLEH
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Protein Length
Partial
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Molecular Weight
113-130 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Siglec-11, a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family, has garnered significant attention in immunological research due to its unique role in modulating the immune response. Expressed primarily on myeloid cells such as macrophages and dendritic cells, Siglec-11 plays a critical role in recognizing sialylated ligands, which are often presented on pathogens and tumor cells, thereby influencing phagocytosis and cell signaling pathways. Notably, Siglec-11 is involved in the regulation of inflammation and has been implicated in various diseases, including cancer and neurodegenerative disorders. Its ability to differentiate between self and non-self through sialic acid recognition makes it a potential target for therapeutic interventions. Research on recombinant Siglec-11 proteins aims to elucidate its functional mechanisms and interactions, providing insights into its role in immune regulation. Additionally, understanding the structural basis of Siglec-11 interactions could pave the way for the development of novel immunomodulatory drugs, potentially enhancing the efficacy of existing therapies and contributing to personalized medicine approaches in treating immune-related conditions. Thus, recombinant Siglec-11 proteins serve as valuable tools for investigating the complexities of the immune system and hold promise for innovative therapeutic strategies.
