Analytical Data
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基因名
LILRB5/CD85c/LIR-8
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简介
The LILRB5/CD85c/LIR-8 protein functions as a receptor for class I MHC antigens, suggesting a critical role in immune recognition and regulation. Its interaction with MHC class I molecules suggests involvement in surveillance and may influence immune responses. LILRB5/CD85c/LIR-8 Protein, Human (433a.a, HEK293, His) is the recombinant human-derived LILRB5/CD85c/LIR-8 protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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别名
Leukocyte immunoglobulin-like receptor subfamily B member 5; LIR-8; CD85c; LILRB5
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种属
Human
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O75023-1
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表达区间
G24-H456
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氨基酸序列
GTLPKPTLWAEPASVIARGKPVTLWCQGPLETEEYRLDKEGLPWARKRQNPLEPGAKAKFHIPSTVYDSAGRYRCYYETPAGWSEPSDPLELVATGFYAEPTLLALPSPVVASGGNVTLQCDTLDGLLTFVLVEEEQKLPRTLYSQKLPKGPSQALFPVGPVTPSCRWRFRCYYYYRKNPQVWSNPSDLLEILVPGVSRKPSLLIPQGSVVARGGSLTLQCRSDVGYDIFVLYKEGEHDLVQGSGQQPQAGLSQANFTLGPVSRSHGGQYRCYGAHNLSPRWSAPSDPLDILIAGLIPDIPALSVQPGPKVASGENVTLLCQSWHQIDTFFLTKEGAAHPPLCLKSKYQSYRHQAEFSMSPVTSAQGGTYRCYSAIRSYPYLLSSPSYPQELVVSGPSGDPSLSPTGSTPTPGPEDQPLTPTGLDPQSGLGRH
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蛋白长度
Extracellular Domain
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分子量
72 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LILRB5, also known as CD85c or LIR-8, is a member of the leukocyte Ig-like receptor (LIR) family, which plays a crucial role in immune regulation. It is primarily expressed on various immune cells, including monocytes, dendritic cells, and T cells, where it serves as an inhibitory receptor that modulates immune responses. The study of LILRB5 is significant due to its potential impact on both innate and adaptive immunity, particularly in the context of autoimmune diseases, infections, and cancer. Research has shown that LILRB5 interacts with MHC class I molecules, contributing to the negative regulation of immune activation and promoting immune tolerance. Understanding the signaling pathways and functional mechanisms associated with LILRB5 is essential for developing therapeutic strategies aimed at enhancing immune responses in cancer immunotherapy or inhibiting unwanted inflammation in autoimmune disorders. The recombinant expression of LILRB5 protein facilitates detailed biochemical and structural studies, providing insights into its ligand interactions and inhibitory functions. Overall, the investigation of LILRB5/CD85c/LIR-8 represents a promising area of research with significant implications for immunology and therapeutic interventions.
