Analytical Data
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基因名
CD84/SLAMF5
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简介
CD84/SLAMF5 is an autoligand receptor of the SLAM family that regulates immune cell activation and differentiation through homotypic or heterotypic interactions. Its activity is affected by SH2D1A/SAP and SH2D1B/EAT-2. CD84/SLAMF5 Protein, Mouse (HEK293, His, solution) is the recombinant mouse-derived CD84/SLAMF5 protein, expressed by HEK293 , with C-10*His labeled tag.
- Application
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生物活性
1. Measured by its ability to bind human SH2D1A in a functional ELISA. 2. Measured by its ability to induce IFN-gamma secretion in CTLL-2 cells. The ED50 for this effect is 0.9762 μg/mL in the presence of 500 ng/mL anti-CD3. Corresponding to a specific activity is 1024.38 U/mg. Measured by its ability to induce IFN-gamma secretion in CTLL-2 cells. The ED50 for this effect is 0.9762 μg/mL in the presence of 500 ng/mL anti-CD3. Corresponding to a specific activity is 1024.38 U/mg.
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别名
CD84; SLAM family member 5; SLAMF5
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种属
Mouse
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表达系统
HEK293
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标签
C-10*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q18PI6-1
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表达区间
K22-V221
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氨基酸序列
KDADPMVMNGILGESVTFLLNIQEPKKIDNIAWTSQSSVAFIKPGVNKAEVTITQGTYKGRIEIIDQKYDLVIRDLRMEDAGTYKADINEENEETITKIYYLHIYRRLKTPKITQSLISSLNNTCNITLTCSVEKEEKDVTYSWSPFGEKSNVLQIVHSPMDQKLTYTCTAQNPVSNSSDSVTVQQPCTDTPSFHPRHAV
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蛋白长度
Extracellular Domain
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分子量
37-42 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD84, also known as SLAMF5, is a member of the SLAM (Signaling Lymphocytic Activation Molecule) family of proteins, which play crucial roles in the regulation of immune responses, particularly in lymphocytes. The research surrounding CD84/SLAMF5 has garnered significant attention due to its implications in various immunological processes, including cell adhesion, activation, and the formation of immune synapses. Expression of CD84 is primarily found in hematopoietic cells, suggesting its pivotal role in immune system regulation. Dysregulation of CD84 signaling has been implicated in several diseases, including autoimmune disorders and cancers, making it a potential target for therapeutic interventions. Recent studies have focused on characterizing the structure and function of CD84/SLAMF5 to elucidate its signaling pathways and interactions with other immune receptors. Moreover, the development of recombinant CD84 proteins holds great promise for further understanding its biological functions, as well as designing novel immunotherapies. Investigating the recombinant form of CD84/SLAMF5 can provide insights into its role in immune modulation and pave the way for innovative strategies to manipulate immune responses in various clinical settings.
